I have an academic background of more than ten years in Genomics both from research and translational diagnostics perspective. Thanks to a brilliant set of academic promoters, I have been able to stay on the forefront of technology as it got introduced in diagnostic setups. Thanks to this early adopter mentality I experienced technologies from their initial phase to their latest, to give an example, my first sequencing experiment was on an Illumina GAIIx, one of the first commercially available next generation sequencers. This career path gave me the tools necessary to understand and apply novel technologies in the best possible manner.

I have also been working since early 2016 as a freelance, assisting the set-up and organization of research and/or diagnostic molecular biology companies. I help strategic decision making over practical and financial issues for medium/large groups in the field.
I am passionate about interdisciplinary approaches which may solve complicated issues, help the translation of research in-to routine diagnostic use, scale-up existing infrastructures, accommodate population scale applications through automation. As a translational researcher I excel at optimizing workflows, implement novel technologies, bridge the gap between clinic/research and lab and between lab and bioinformatics.

 

 

 

 

 

KU Leuven – Research Associate

 

2019 – 2021

I have spent this period in Laboratory of Human Genetics and Genome Research – Department of Human Genetics, Katholieke Universiteit Leuven under the supervision of Joris Vermeesch, focusing mainly on Next Generation Sequencing applications. I supported PhD students and post-docs, troubleshot their research as well as organize and provide support for different work-teams. I was involved in projects covering a variety of different molecular biology technologies, source materials and end-applications. I also provided support for the automation of workflows and gave a hand to the medical diagnostics team.

UZ Leuven – Consultant

2017 – 2019

Management of personnel of 12 during the transition period of obligatory scale up because of the NIPT surge. Created installed, implemented and trained personnel for high-throughput automated liquid handling setup for NIPT (et. al.) that is capable of handling more than thousand samples daily using only 3 people while reducing the production cost and reproducibility, all of which without hindering ongoing production. During my downtime I have collaborated with Genomics Core of KUL/UZL to automate some of their internal processes, create collaborations with research groups and jump-start new projects.

University of Pavia – Research associate

2014 – 2015

Laboratory setup to enable internal Next Generation Sequencing workflows and analysis. Implementation of custom and whole exome panels. Personnel organization and training. Internal IT-network structuring and installation of database backup systems as well as LIMS. Internal SOP creation and validation of new diagnostic tests.

 

 

 

 

 

 

 

Pubblications

 

Systematic evaluation of NIPT aneuploidy detection software tools with clinically validated NIPT samples.

Paluoja P, Teder H, Ardeshirdavani A, Bayindir B, Vermeesch J, Salumets A, Krjutškov K, Palta P. 

PLoS Comput Biol. 2021 Dec 20;17(12):e1009684. doi: 10.1371/journal.pcbi.1009684. eCollection 2021 Dec.

 

Fetal sex determination in twin pregnancies using non-invasive prenatal testing.

Villela D, Che H, Van Ghelue M, Dehaspe L, Brison N, Van Den Bogaert K, Devriendt K, Lewi L, Bayindir B, Vermeesch JR. 

NPJ Genom Med. 2019 Jul 4;4:15. doi: 10.1038/s41525-019-0089-4. eCollection 2019.

 

Predicting fetoplacental chromosomal mosaicism during non-invasive prenatal testing.

Brison N, Neofytou M, Dehaspe L, Bayindir B, Van Den Bogaert K, Dardour L, Peeters H, Van Esch H, Van Buggenhout G, Vogels A, de Ravel T, Legius E, Devriendt K, Vermeesch JR.

Prenat Diagn. 2018 Mar;38(4):258-266. doi: 10.1002/pd.5223. Epub 2018 Feb 19.

 

Non-Invasive Prenatal Testing (NIPT) using a novel analysis pipeline to screen for all autosomal fetal aneuploidies improves pregnancy management

Bayindir B., Dehaspe L., Brison N., Brady P., Ardui S., Kamoun M., Van der Veken L, Lichtenbelt K, Van den Bogaert K, Van Houdt J, Peeters H, Van Esch H, de Ravel T, Legius E, Devriendt K, Vermeesch JR.

Eur J Hum Genet. 2015 Jan 14. doi: 10.1038/ejhg.2014.282. [Epub ahead of print]

 

Improving molecular diagnosis in epilepsy by a dedicated high-throughput sequencing platform.

Della Mina E, Ciccone R, Brustia F, Bayindir B, Limongelli I, Vetro A, Iascone M, Pezzoli L, Bellazzi R, Perotti G, De

Giorgis V, Lunghi S, Coppola G, Orcesi S, Merli P, Savasta S, Veggiotti P, Zuffardi O.

Eur J Hum Genet. 2014 May 21. doi: 10.1038/ejhg.2014.92. [Epub ahead of print]

 

Dravet phenotype in a subject with a der(4)t(4;8)(p16.3;p23.3) without the involvement of the LETM1 gene.

Bayindir B, Piazza E, Della Mina E, Limongelli I, Brustia F, Ciccone R, Veggiotti P, Zuffardi O, Dehghani MR.

Eur J Med Genet. 2013 Oct;56(10):551-5. doi: 10.1016/j.ejmg.2013.08.003. Epub 2013 Aug 31.

 

Idiopathic central precocious puberty associated with 11?mb de novo distal deletion of the chromosome 9 short arm.

Cisternino M, Della Mina E, Losa L, Madè A, Rossetti G, Bassi LA, Pieri G, Bayindir B, Messa J, Zuffardi O, Ciccone R.

Case Rep Genet. 2013;2013:978087. doi: 10.1155/2013/978087. Epub 2013 Jul 31.