University of Cagliari
Laura Valdes
Rational structure-based design and optimization of next-generation biphenyl-piperidine-triazine derivatives as potent non-nucleoside reverse transcriptase inhibitors
2026-01-01 Zhang, Kun; Zhao, Li-Min; Xing, Tianhao; Bu, Yueyue; Wang, Qingyun; Pannecouque, Christophe; De Clercq, Erik; Corona, Angela; Dettori, Laura; Tramontano, Enzo; Wang, Shuai; Chen, Fen-Er
Infectious Diseases Research in the Global South: Treatments and Treatment Failures
2026-01-01 Wicht, Kathryn; Ganesan, Sandhya; Corona, Angela; Matange, Nishad
2‐Phenylquinolines Exhibit Anti‐Severe Acute Respiratory Syndrome Coronavirus‐2 Activity Through the Nonstructural Protein 13 Helicase Inhibition
2026-01-01 Cernicchi, Giada; Nizi, Maria Giulia; Emmolo, Roberta; Persoons, Leentje; Laporte, Manon; Jochmans, Dirk; Romeo, Isabella; Pepe, Giacomo; Milite, Ciro; Campiglia, Pietro; Spezzini, Jacopo; Martelli, Alma; Brogi, Simone; Esposito, Francesca; Felicetti, Tommaso; Massari, Serena; Manfroni, Giuseppe; Sabatini, Stefano; Sbardella, Gianluca; Alcaro, Stefano; Neyts, Johan; Corona, Angela; Tramontano, Enzo; De Jonghe, Steven; Tabarrini, Oriana
Identification of Nsp15 inhibitors restoring interferon-dependent antiviral activity against SARS-CoV-2
2026-01-01 Maloccu, Stefania; Otsuka, Yuka; Molchan, Elizabeth; Foti, Michelle; Paulis, Annalaura; Vishwakarma, Jyoti; Malune, Paolo; Cottiglia, Filippo; Corona, Angela; Scampavia, Louis; Spicer, Timothy P.; Harris, Reuben S.; Tramontano, Enzo; Fanunza, Elisa
Identification of HIV-1 Reverse Transcriptase-Associated Ribonuclease H Inhibitors Based on 2-Hydroxy-1,4-naphthoquinone Mannich Bases
2025-01-01 Tu, Nhat Quang; Richetta, Clémence; Putzu, Federica; Delelis, Olivier; Ahmed, Khursheed; Masand, Vijay H.; Schobert, Rainer; Tramontano, Enzo; Corona, Angela; Biersack, Bernhard
Design, and synthesis of 2,4-thiazolidinedione substituted 1–3-5-triazine derivatives as anti-HIV agent via inhibition of reverse transcriptase along with anti-SARS CoV-2, antibacterial and antibiofilm activity
2025-01-01 Singh, Saumya; Srivastava, Kumar Saurabh; Gahtori, Prashant; Anand, Ananya Anurag; Samanta, Sintu Kumar; Kumawat, Mukesh Kumar; Bhat, Hans Raj; Corona, Angela; Tramontano, Enzo; Mitra, Debashis; Singh, Udaya Pratap
Dual-Site Inhibition of SARS-CoV2 RNA-Dependent RNA Polymerase by Small Molecules Able to Block Viral Replication Identified through a Computer-Aided Drug Discovery Approach
2025-01-01 Malune, Paolo; Iaconis, Daniela; Manelfi, Candida; Giunta, Stefano; Emmolo, Roberta; Lunghini, Filippo; Paulis, Annalaura; Talarico, Carmine; Corona, Angela; Rosario Beccari, Andrea; Tramontano, Enzo; Esposito, Francesca
Design, Synthesis and Biological Evaluation of 3-Hydrazonoindolin-2-one Derivatives as Novel HIV-1 RNase H Inhibitors
2025-01-01 Zhang, Yiying; Wang, Rao; Bu, Yueyue; Corona, Angela; Dettori, Laura; Tramontano, Enzo; Pannecouque, Christophe; De Clercq, Erik; Wang, Shuai; Meng, Ge; Chen, Fen-Er
Thiol-Reactive or Redox-Active: Revising a Repurposing Screen Led to a New Invalidation Pipeline and Identified a True Noncovalent Inhibitor Against Papain-like Protease from SARS-CoV-2
2025-01-01 Kuzikov, Maria; Morasso, Stefano; Reinshagen, Jeanette; Wolf, Markus; Monaco, Vittoria; Cozzolino, Flora; Golič Grdadolnik, Simona; Šket, Primož; Plavec, Janez; Iaconis, Daniela; Summa, Vincenzo; Corona, Angela; Paulis, Annalaura; Esposito, Francesca; Tramontano, Enzo; Monti, Maria; Beccari, Andrea R.; Manelfi, Candida; Windshügel, Björn; Gribbon, Philip; Storici, Paola; Zaliani, Andrea
Identifying potential allosteric inhibitors of ZIKV NS3pro through a combined computational and biochemical approach
2025-01-01 Demuru, L.; Lupia, A.; Nieddu, S.; Emmolo, R.; Paulis, A.; Esposito, F.; Distinto, S.; Bryant, S. D.; Onali, A.; Sanna, E.; Atzeni, G.; Cottiglia, F.; Grandi, N.; Corona, A.; Tramontano, E.; Maccioni, E.; Meleddu, R.
Structure−Activity Relationships of New 1‐Aryl‐1H‐Indole Derivatives as SARS‐CoV‐2 Nsp13 Inhibitors
2025-01-01 Madia, Valentina Noemi; Emmolo, Roberta; Patacchini, Elisa; Amatore, Donatella; Maloccu, Stefania; Ialongo, Davide; Albano, Aurora; Ruggieri, Giuseppe; Cara, Emanuele; Zarbo, Laura; Messore, Antonella; De Santis, Riccardo; Amoroso, Alessandra; Lista, Florigio; Esposito, Francesca; Tramontano, Enzo; Corona, Angela; Di Santo, Roberto; Costi, Roberta
Structure-Based Discovery of Novel Diarylpyrimidines as Potent and Selective Non-Nucleoside Reverse Transcriptase Inhibitors: From CH(CN)-Biphenyl-Diarylpyrimidines to C=NNH2-Biphenyl-Diarylpyrimidines
2025-01-01 Chen, Xiao-Mei; Pannecouque, Christophe; De Clercq, Erik; Lian, Yu-Xuan; Corona, Angela; Dettori, Laura; Tramontano, Enzo; Wang, Shuai; Chen, Fen-Er
Synthesis and Evaluation of Thiazolidinone-Isatin Hybrids for Selective Inhibition of Cancer-Related Carbonic Anhydrases
2025-01-01 Onali, A.; Sanna, E.; Lupia, A.; Secci, D.; Atzeni, G.; Demuru, L.; Angeli, A.; Cottiglia, F.; Meleddu, R.; Emmolo, R.; Corona, A.; Maccioni, E.; Supuran, C. T.; Distinto, S.
Meeting report: Seventh summer school on innovative approaches for identification of antiviral agents (IAAASS)
2025-01-01 Corona, Angela; Cagno, Valeria; Grandi, Nicole; Fanunza, Elisa; Esposito, Francesca; Seley-Radtke, Kathie L.; Tramontano, Enzo
Tiazolidinoni come agenti antivirali
2025-01-01 Distinto, Simona; Corona, Angela; Sanna, Erica; Tramontano, Enzo; Maccioni, Elias; Scognamiglio, Sante; Onali, Alessia; Cottiglia, Filippo; Meleddu, Rita; Secci, Daniela; Maloccu, Stefania
N -alkyl and N-benzyl indoles are anti-SARS-CoV-2 agents and nsp13 inhibitors
2025-01-01 Albano, Aurora; Emmolo, Roberta; De Santis, Riccardo; Patacchini, Elisa; Madia, Valentina Noemi; Maloccu, Stefania; Ialongo, Davide; Ruggieri, Giuseppe; Arpacioglu, Merve; Scipione, Luigi; Saccoliti, Francesco; Amatore, Donatella; Grilli, Giorgia; Lista, Florigio; Esposito, Francesca; Tramontano, Enzo; Corona, Angela; Di Santo, Roberto; Costi, Roberta
The efficiency of high-throughput screening (HTS) and in-silico data analysis during medical emergencies: Identification of effective antiviral 3CLpro inhibitors
2025-01-01 Zian, D.; Iaconis, D.; Nenci, S.; Crusco, A.; Tawde, S.; Sodano, M.; Vitalone, R.; Raje, A.; Palamini, M.; Carettoni, D.; Molteni, A.; Manelfi, C.; Tazzari, V.; Beccari, A. R.; Malune, P.; Maloccu, S.; Paulis, Annalaura; Corona, Angela; Nieddu, Salvatore; Coletti, S.; Scarabottolo, L.; Tramontano, Enzo; Esposito, Francesca; Catalani, M.
New Thiazolidine-4-One Derivatives as SARS-CoV-2 Main Protease Inhibitors
2024-01-01 Messore, Antonella; Malune, Paolo; Patacchini, Elisa; Noemi Madia, Valentina; Ialongo, Davide; Arpacioglu, Merve; Albano, Aurora; Ruggieri, Giuseppe; Saccoliti, Francesco; Scipione, Luigi; Tramontano, Enzo; Canton, Serena; Corona, Angela; Scognamiglio, Sante; Paulis, Annalaura; Suleiman, Mustapha; Mohammed Al-Maqtari, Helmi; Abid, Fatma Mohamed A.; Kawsar, Sarkar M. A.; Sankaranarayanan, Murugesan; Di Santo, Roberto; Esposito, Francesca; Roberta Costi, And
4-(3-Phenylsulfonylindol-2-yl)-1-(pyridin-2-yl)piperazinyl-methanones as Potent Inhibitors of both SARS-CoV-2 and HCoV-OC43 Viruses
2024-01-01 Puxeddu, M.; Donalisio, M.; Bugert, J. J.; Corona, Angela; Cocomazzi, P.; Milani, M.; Hucke, F.; Arduino, I.; Esposito, Francesca; Moretti, P.; Ortore, M. G.; Nalli, M.; Manetto, S.; Mazzoccanti, G.; Bigogno, C.; Dondio, G.; Scio, P.; Coluccia, A.; Fracella, M.; Antonelli, G.; Lembo, D.; Tramontano, Enzo; Silvestri, R.; Mastrangelo, E.; La Regina, G.
Call for Papers: Infectious Diseases Research in the Global South: Treatments and Treatment Failures
2024-01-01 Corona, Angela; Ganesan, Sandhya; Matange, Nishad; Wicht, Kathryn
Structure-Based Design of Novel Thiazolone[3,2-a]pyrimidine Derivatives as Potent RNase H Inhibitors for HIV Therapy
2024-01-01 Zhu, X. -D.; Corona, A.; Maloccu, S.; Tramontano, E.; Wang, S.; Pannecouque, C.; De Clercq, E.; Meng, G.; Chen, F. -E.
Design, synthesis and biological evaluation of Thiazolo[3, 2-a]Pyrimidine derivatives as novel RNase H inhibitors
2024-01-01 Zhao, K. -X.; Zhang, Y. -Y.; Wang, J. -S.; Wang, S.; Corona, A.; Maloccu, S.; Tramontano, E.; Pannecouque, C.; De Clercq, E.; Meng, G.; Wang, L.; Chen, F. -E.
Expanding the Solvent/Protein Region Occupation of the Non-Nucleoside Reverse Transcriptase Inhibitor Binding Pocket for Improved Broad-Spectrum Anti-HIV-1 Efficacy: from Rigid Phenyl-Diarylpyrimidines to Flexible Hydrophilic Piperidine-Diarylpyrimidines
2024-01-01 Huang, Wen-Juan; Pannecouque, Christophe; De Clercq, Erik; Corona, Angela; Maloccu, Stefania; Tramontano, Enzo; Wang, Shuai; Chen, Fen-Er
Drug repurposing screen to identify inhibitors of the RNA polymerase (nsp12) and helicase (nsp13) from SARS-CoV-2 replication and transcription complex
2024-01-01 Kuzikov, Maria; Reinshagen, Jeanette; Wycisk, Krzysztof; Corona, Angela; Esposito, Francesca; Malune, Paolo; Manelfi, Candida; Iaconis, Daniela; Beccari, Andrea; Tramontano, Enzo; Nowotny, Marcin; Windshügel, Bjorn; Gribbon, Philip; Zaliani, Andrea
Identification of new benzofuran derivatives as STING agonists with broad-spectrum antiviral activity
2024-01-01 Paulis, A.; Onali, A.; Vidalain, P. O.; Lotteau, V.; Jaquemin, C.; Corona, A.; Distinto, S.; Delogu, G. L.; Tramontano, E.
Broad-spectrum coronavirus 3C-like protease peptidomimetic inhibitors effectively block SARS-CoV-2 replication in cells: Design, synthesis, biological evaluation, and X-ray structure determination
2023-01-01 Stefanelli, Irina; Corona, Angela; Cerchia, Carmen; Cassese, Emilia; Improta, Salvatore; Costanzi, Elisa; Pelliccia, Sveva; Morasso, Stefano; Esposito, Francesca; Paulis, Annalaura; Scognamiglio, Sante; Di Leva, Francesco Saverio; Storici, Paola; Brindisi, Margherita; Tramontano, Enzo; Cannalire, Rolando; Summa, Vincenzo
METODO DI STIMA DI PARAMETRI DI VIRUS IN UN CAMPIONE DI MATERIALE BIOLOGICO
2023-01-01 Chiriu, Daniele; Tramontano, Enzo; Corona, Angela; Carbonaro, Carlo Maria; David, Tullia Carla; Porcu, Stefania; Ricci, Pier Carlo
Versatile anti-infective properties of pyrido- and dihydropyrido[2,3-d]pyrimidine-based compounds
2023-01-01 Al Nasr, Ibrahim S; Corona, Angela; Koko, Waleed S; Khan, Tariq A; Ben Said, Ridha; Daoud, Ismail; Rahali, Seyfeddine; Tramontano, Enzo; Schobert, Rainer; Amdouni, Noureddine; Biersack, Bernhard
Targeting SARS-CoV-2 Main Protease: A Successful Story Guided by an In Silico Drug Repurposing Approach
2023-01-01 Alessandra Ambrosio, Francesca; Costa, Giosuè; Romeo, Isabella; Esposito, Francesca; Alkhatib, Mohammad; Salpini, Romina; Svicher, Valentina; Corona, Angela; Malune, Paolo; Tramontano, Enzo; Ceccherini-Silberstein, Francesca; Alcaro, Stefano; Anna Artese, And
DHFR Inhibitors Display a Pleiotropic Anti-Viral Activity against SARS-CoV-2: Insights into the Mechanisms of Action
2023-01-01 Iaconis, Daniela; Caccuri, Francesca; Manelfi, Candida; Talarico, Carmine; Bugatti, Antonella; Filippini, Federica; Zani, Alberto; Novelli, Rubina; Kuzikov, Maria; Ellinger, Bernhard; Gribbon, Philip; Riecken, Kristoffer; Esposito, Francesca; Corona, Angela; Tramontano, Enzo; Beccari, Andrea Rosario; Caruso, Arnaldo; Allegretti, Marcello
Visible Light-Mediated Inactivation of H1N1 Virus UsingPolymer-Based Heterojunction Photocatalyst
2023-01-01 Porcu, Stefania; Maloccu, Stefania; Corona, Angela; Hazra, Moulika; David, TULLIA CARLA; Chiriu, Daniele; Carbonaro, CARLO MARIA; Tramontano, Enzo; Ricci, PIER CARLO
Suramin inhibits SARS-CoV-2 nucleocapsid phosphoprotein genome packaging function
2023-01-01 Boniardi, Irene; Corona, Angela; Basquin, Jerome; Basquin, Claire; Milia, Jessica; Nagy, István; Tramontano, Enzo; Zinzula, Luca
5-Nitro-3-(2-(4-phenylthiazol-2-yl)hydrazineylidene)indolin-2-one derivatives inhibit HIV-1 replication by a multitarget mechanism of action
2023-01-01 Corona, A.; Meleddu, R.; Delelis, O.; Subra, F.; Cottiglia, F.; Esposito, F.; Distinto, S.; Maccioni, E.; Tramontano, E.
HIV-1 Integrase Inhibition Activity by Spiroketals Derived from Plagius flosculosus, an Endemic Plant of Sardinia (Italy) and Corsica (France)
2023-01-01 Sanna, Cinzia; D’Abrosca, Brigida; Fiorentino, Antonio; Giammarino, Federica; Vicenti, Ilaria; Corona, Angela; Caredda, Alessia; Tramontano, Enzo; Esposito, Francesca
Analogs of the Catechol Derivative Dynasore Inhibit HIV-1 Ribonuclease H, SARS-CoV-2 nsp14 Exoribonuclease, and Virus Replication
2023-01-01 Asthana, A.; Corona, A.; Shin, W. -J.; Kwak, M. -J.; Gaughan, C.; Tramontano, E.; Jung, J. U.; Schobert, R.; Jha, B. K.; Silverman, R. H.; Biersack, B.
Editorial: Viruses, innate immunity, and antiviral strategies: from basic research to clinical applications
2023-01-01 Fanunza, Elisa; Corona, Angela
Naïve antibody library derived monoclonal antibody against VP35 of Ebola virus
2023-01-01 Lai, Jing Yi; Corona, Angela; Ng, Chong Lee; Tramontano, Enzo; Choong, Yee Siew; Lim, Theam Soon
Diketo acid inhibitors of nsp13 of SARS-CoV-2 block viral replication
2023-01-01 Corona, Angela; Madia, Valentina Noemi; De Santis, Riccardo; Manelfi, Candida; Emmolo, Roberta; Ialongo, Davide; Patacchini, Elisa; Messore, Antonella; Amatore, Donatella; Faggioni, Giovanni; Artico, Marco; Iaconis, Daniela; Talarico, Carmine; Di Santo, Roberto; Lista, Florigio; Costi, Roberta; Tramontano, Enzo
Ebola virus disease: In vivo protection provided by the PAMP restricted TLR3 agonist rintatolimod and its mechanism of action
2023-01-01 Corona, Angela; Strayer, David; Distinto, Simona; Daino, Gian Luca; Paulis, Annalaura; Tramontano, Enzo; Mitchell, William M
Discovery of 2-Phenylquinolines with Broad-Spectrum Anti-coronavirus Activity
2022-01-01 Nizi, Maria Giulia; Persoons, Leentje; Corona, Angela; Felicetti, Tommaso; Cernicchi, Giada; Massari, Serena; Manfroni, Giuseppe; Vangeel, Laura; Barreca, Maria Letizia; Esposito, Francesca; Jochmans, Dirk; Milia, Jessica; Cecchetti, Violetta; Schols, Dominique; Neyts, Johan; Tramontano, Enzo; Sabatini, Stefano; De Jonghe, Steven; Tabarrini, Oriana
Cytopathic SARS-CoV-2 screening on VERO-E6 cells in a large-scale repurposing effort
2022-01-01 Zaliani, Andrea; Vangeel, Laura; Reinshagen, Jeanette; Iaconis, Daniela; Kuzikov, Maria; Keminer, Oliver; Wolf, Markus; Ellinger, Bernhard; Esposito, Francesca; Corona, Angela; Tramontano, Enzo; Manelfi, Candida; Herzog, Katja; Jochmans, Dirk; De Jonghe, Steven; Chiu, Winston; Francken, Thibault; Schepers, Joost; Collard, Caroline; Abbasi, Kayvan; Claussen, Carsten; Summa, Vincenzo; Beccari, Andrea R.; Neyts, Johan; Gribbon, Philip; Leyssen, Pieter
Targeting SARS-CoV-2 nsp13 Helicase and Assessment of Druggability Pockets: Identification of Two Potent Inhibitors by a Multi-Site In Silico Drug Repurposing Approach
2022-01-01 Romeo, Isabella; Ambrosio, Francesca Alessandra; Costa, Giosuè; Corona, Angela; Alkhatib, Mohammad; Salpini, Romina; Lemme, Saverio; Vergni, Davide; Svicher, Valentina; Santoro, Maria Mercedes; Tramontano, Enzo; Ceccherini-Silberstein, Francesca; Artese, Anna; Alcaro, Stefano
Cynarin blocks Ebola virus replication by counteracting VP35 inhibition of interferon-beta production
2022-01-01 Corona, Angela; Fanunza, Elisa; Salata, Cristiano; Morwitzer, Melody Jane; Distinto, Simona; Zinzula, Luca; Sanna, Cinzia; Frau, Aldo; Daino, Gian Luca; Quartu, Marina; Taglialatela-Scafati, Orazio; Rigano, Daniela; Reid, Stpatrick; Mirazimi, Alì; Tramontano, Enzo
Easy access to α-ketoamides as SARS-CoV-2 and MERS Mpro inhibitors via the PADAM oxidation route
2022-01-01 Pelliccia, Sveva; Cerchia, Carmen; Esposito, Francesca; Cannalire, Rolando; Corona, Angela; Costanzi, Elisa; Kuzikov, Maria; Gribbon, Philip; Zaliani, Andrea; Brindisi, Margherita; Storici, Paola; Tramontano, Enzo; Summa, Vincenzo
Mutations in the 3'-PPT Lead to HIV-1 Replication without Integration
2022-01-01 Richetta, Clémence; Subra, Frédéric; Malet, Isabelle; Leh, Hervé; Charpentier, Charlotte; Corona, Angela; Collin, Gilles; Descamps, Diane; Deprez, Eric; Parissi, Vincent; Calvez, Vincent; Tramontano, Enzo; Marcelin, Anne-Geneviève; Delelis, Olivier
Natural Compounds Inhibit SARS-CoV-2 nsp13 Unwinding and ATPase Enzyme Activities
2022-01-01 Corona, Angela; Wycisk, Krzysztof; Talarico, Carmine; Manelfi, Candida; Milia, Jessica; Cannalire, Rolando; Esposito, Francesca; Gribbon, Philip; Zaliani, Andrea; Iaconis, Daniela; Beccari, Andrea R.; Summa, Vincenzo; Nowotny, Marcin; Tramontano, Enzo
Garcinol from Garcinia indica inhibits HIV-1 reverse transcriptase-associated ribonuclease H
2021-01-01 Corona, Angela; Seibt, Sebastian; Schaller, David; Schobert, Rainer; Volkamer, Andrea; Biersack, Bernhard; Tramontano, Enzo
Inhibitors of Ebolavirus targeting innate immune evasion
2021-01-01 Paulis, A. L.; Corona, A.; Tramontano, E.
Natural and Nature-Derived Products Targeting Human Coronaviruses
2021-01-01 Vougogiannopoulou, Konstantina; Corona, Angela; Tramontano, Enzo; Alexis, Michael N.; Skaltsounis, Alexios-Leandros
Flavonoids and Acid-Hydrolysis derivatives of Neo-Clerodane diterpenes from Teucrium flavum subsp. glaucum as inhibitors of the HIV-1 reverse transcriptase–associated RNase H function
2021-01-01 Fois, Benedetta; Corona, Angela; Tramontano, Enzo; Distinto, Simona; Maccioni, Elias; Meleddu, Rita; Caboni, Pierluigi; Floris, Costantino; Cottiglia, Filippo
| Title | Issue Date | Author(s) | Journal | Publisher |
|---|---|---|---|---|
| Rational structure-based design and optimization of next-generation biphenyl-piperidine-triazine derivatives as potent non-nucleoside reverse transcriptase inhibitors | 1-Jan-2026 | Zhang, Kun; Zhao, Li-Min; Xing, Tianhao; Bu, Yueyue; Wang, Qingyun; Pannecouque, Christophe; De Clercq, Erik; Corona, Angela; Dettori, Laura; Tramontano, Enzo; Wang, Shuai; Chen, Fen-Er | CHINESE CHEMICAL LETTERS | - |
| Infectious Diseases Research in the Global South: Treatments and Treatment Failures | 1-Jan-2026 | Wicht, Kathryn; Ganesan, Sandhya; Corona, Angela; Matange, Nishad | ACS INFECTIOUS DISEASES | - |
| 2‐Phenylquinolines Exhibit Anti‐Severe Acute Respiratory Syndrome Coronavirus‐2 Activity Through the Nonstructural Protein 13 Helicase Inhibition | 1-Jan-2026 | Cernicchi, Giada; Nizi, Maria Giulia; Emmolo, Roberta; Persoons, Leentje; Laporte, Manon; Jochmans, Dirk; Romeo, Isabella; Pepe, Giacomo; Milite, Ciro; Campiglia, Pietro; Spezzini, Jacopo; Martelli, Alma; Brogi, Simone; Esposito, Francesca; Felicetti, Tommaso; Massari, Serena; Manfroni, Giuseppe; Sabatini, Stefano; Sbardella, Gianluca; Alcaro, Stefano; Neyts, Johan; Corona, Angela; Tramontano, Enzo; De Jonghe, Steven; Tabarrini, Oriana | CHEMMEDCHEM | - |
| Identification of Nsp15 inhibitors restoring interferon-dependent antiviral activity against SARS-CoV-2 | 1-Jan-2026 | Maloccu, Stefania; Otsuka, Yuka; Molchan, Elizabeth; Foti, Michelle; Paulis, Annalaura; Vishwakarma, Jyoti; Malune, Paolo; Cottiglia, Filippo; Corona, Angela; Scampavia, Louis; Spicer, Timothy P.; Harris, Reuben S.; Tramontano, Enzo; Fanunza, Elisa | ANTIVIRAL RESEARCH | - |
| Identification of HIV-1 Reverse Transcriptase-Associated Ribonuclease H Inhibitors Based on 2-Hydroxy-1,4-naphthoquinone Mannich Bases | 1-Jan-2025 | Tu, Nhat Quang; Richetta, Clémence; Putzu, Federica; Delelis, Olivier; Ahmed, Khursheed; Masand, Vijay H.; Schobert, Rainer; Tramontano, Enzo; Corona, Angela; Biersack, Bernhard | MOLECULES | - |
| Design, and synthesis of 2,4-thiazolidinedione substituted 1–3-5-triazine derivatives as anti-HIV agent via inhibition of reverse transcriptase along with anti-SARS CoV-2, antibacterial and antibiofilm activity | 1-Jan-2025 | Singh, Saumya; Srivastava, Kumar Saurabh; Gahtori, Prashant; Anand, Ananya Anurag; Samanta, Sintu Kumar; Kumawat, Mukesh Kumar; Bhat, Hans Raj; Corona, Angela; Tramontano, Enzo; Mitra, Debashis; Singh, Udaya Pratap | BIOORGANIC CHEMISTRY | - |
| Dual-Site Inhibition of SARS-CoV2 RNA-Dependent RNA Polymerase by Small Molecules Able to Block Viral Replication Identified through a Computer-Aided Drug Discovery Approach | 1-Jan-2025 | Malune, Paolo; Iaconis, Daniela; Manelfi, Candida; Giunta, Stefano; Emmolo, Roberta; Lunghini, Filippo; Paulis, Annalaura; Talarico, Carmine; Corona, Angela; Rosario Beccari, Andrea; Tramontano, Enzo; Esposito, Francesca | ACS INFECTIOUS DISEASES | - |
| Design, Synthesis and Biological Evaluation of 3-Hydrazonoindolin-2-one Derivatives as Novel HIV-1 RNase H Inhibitors | 1-Jan-2025 | Zhang, Yiying; Wang, Rao; Bu, Yueyue; Corona, Angela; Dettori, Laura; Tramontano, Enzo; Pannecouque, Christophe; De Clercq, Erik; Wang, Shuai; Meng, Ge; Chen, Fen-Er | MOLECULES | - |
| Thiol-Reactive or Redox-Active: Revising a Repurposing Screen Led to a New Invalidation Pipeline and Identified a True Noncovalent Inhibitor Against Papain-like Protease from SARS-CoV-2 | 1-Jan-2025 | Kuzikov, Maria; Morasso, Stefano; Reinshagen, Jeanette; Wolf, Markus; Monaco, Vittoria; Cozzolino, Flora; Golič Grdadolnik, Simona; Šket, Primož; Plavec, Janez; Iaconis, Daniela; Summa, Vincenzo; Corona, Angela; Paulis, Annalaura; Esposito, Francesca; Tramontano, Enzo; Monti, Maria; Beccari, Andrea R.; Manelfi, Candida; Windshügel, Björn; Gribbon, Philip; Storici, Paola; Zaliani, Andrea | ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE | - |
| Identifying potential allosteric inhibitors of ZIKV NS3pro through a combined computational and biochemical approach | 1-Jan-2025 | Demuru, L.; Lupia, A.; Nieddu, S.; Emmolo, R.; Paulis, A.; Esposito, F.; Distinto, S.; Bryant, S. D.; Onali, A.; Sanna, E.; Atzeni, G.; Cottiglia, F.; Grandi, N.; Corona, A.; Tramontano, E.; Maccioni, E.; Meleddu, R. | - | - |
| Structure−Activity Relationships of New 1‐Aryl‐1H‐Indole Derivatives as SARS‐CoV‐2 Nsp13 Inhibitors | 1-Jan-2025 | Madia, Valentina Noemi; Emmolo, Roberta; Patacchini, Elisa; Amatore, Donatella; Maloccu, Stefania; Ialongo, Davide; Albano, Aurora; Ruggieri, Giuseppe; Cara, Emanuele; Zarbo, Laura; Messore, Antonella; De Santis, Riccardo; Amoroso, Alessandra; Lista, Florigio; Esposito, Francesca; Tramontano, Enzo; Corona, Angela; Di Santo, Roberto; Costi, Roberta | CHEMMEDCHEM | - |
| Structure-Based Discovery of Novel Diarylpyrimidines as Potent and Selective Non-Nucleoside Reverse Transcriptase Inhibitors: From CH(CN)-Biphenyl-Diarylpyrimidines to C=NNH2-Biphenyl-Diarylpyrimidines | 1-Jan-2025 | Chen, Xiao-Mei; Pannecouque, Christophe; De Clercq, Erik; Lian, Yu-Xuan; Corona, Angela; Dettori, Laura; Tramontano, Enzo; Wang, Shuai; Chen, Fen-Er | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - |
| Synthesis and Evaluation of Thiazolidinone-Isatin Hybrids for Selective Inhibition of Cancer-Related Carbonic Anhydrases | 1-Jan-2025 | Onali, A.; Sanna, E.; Lupia, A.; Secci, D.; Atzeni, G.; Demuru, L.; Angeli, A.; Cottiglia, F.; Meleddu, R.; Emmolo, R.; Corona, A.; Maccioni, E.; Supuran, C. T.; Distinto, S. | ACS MEDICINAL CHEMISTRY LETTERS | - |
| Meeting report: Seventh summer school on innovative approaches for identification of antiviral agents (IAAASS) | 1-Jan-2025 | Corona, Angela; Cagno, Valeria; Grandi, Nicole; Fanunza, Elisa; Esposito, Francesca; Seley-Radtke, Kathie L.; Tramontano, Enzo | ANTIVIRAL RESEARCH | - |
| Tiazolidinoni come agenti antivirali | 1-Jan-2025 | Distinto, Simona; Corona, Angela; Sanna, Erica; Tramontano, Enzo; Maccioni, Elias; Scognamiglio, Sante; Onali, Alessia; Cottiglia, Filippo; Meleddu, Rita; Secci, Daniela; Maloccu, Stefania | - | - |
| N -alkyl and N-benzyl indoles are anti-SARS-CoV-2 agents and nsp13 inhibitors | 1-Jan-2025 | Albano, Aurora; Emmolo, Roberta; De Santis, Riccardo; Patacchini, Elisa; Madia, Valentina Noemi; Maloccu, Stefania; Ialongo, Davide; Ruggieri, Giuseppe; Arpacioglu, Merve; Scipione, Luigi; Saccoliti, Francesco; Amatore, Donatella; Grilli, Giorgia; Lista, Florigio; Esposito, Francesca; Tramontano, Enzo; Corona, Angela; Di Santo, Roberto; Costi, Roberta | JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | - |
| The efficiency of high-throughput screening (HTS) and in-silico data analysis during medical emergencies: Identification of effective antiviral 3CLpro inhibitors | 1-Jan-2025 | Zian, D.; Iaconis, D.; Nenci, S.; Crusco, A.; Tawde, S.; Sodano, M.; Vitalone, R.; Raje, A.; Palamini, M.; Carettoni, D.; Molteni, A.; Manelfi, C.; Tazzari, V.; Beccari, A. R.; Malune, P.; Maloccu, S.; Paulis, Annalaura; Corona, Angela; Nieddu, Salvatore; Coletti, S.; Scarabottolo, L.; Tramontano, Enzo; Esposito, Francesca; Catalani, M. | ANTIVIRAL RESEARCH | - |
| New Thiazolidine-4-One Derivatives as SARS-CoV-2 Main Protease Inhibitors | 1-Jan-2024 | Messore, Antonella; Malune, Paolo; Patacchini, Elisa; Noemi Madia, Valentina; Ialongo, Davide; Arpacioglu, Merve; Albano, Aurora; Ruggieri, Giuseppe; Saccoliti, Francesco; Scipione, Luigi; Tramontano, Enzo; Canton, Serena; Corona, Angela; Scognamiglio, Sante; Paulis, Annalaura; Suleiman, Mustapha; Mohammed Al-Maqtari, Helmi; Abid, Fatma Mohamed A.; Kawsar, Sarkar M. A.; Sankaranarayanan, Murugesan; Di Santo, Roberto; Esposito, Francesca; Roberta Costi, And | PHARMACEUTICALS | - |
| 4-(3-Phenylsulfonylindol-2-yl)-1-(pyridin-2-yl)piperazinyl-methanones as Potent Inhibitors of both SARS-CoV-2 and HCoV-OC43 Viruses | 1-Jan-2024 | Puxeddu, M.; Donalisio, M.; Bugert, J. J.; Corona, Angela; Cocomazzi, P.; Milani, M.; Hucke, F.; Arduino, I.; Esposito, Francesca; Moretti, P.; Ortore, M. G.; Nalli, M.; Manetto, S.; Mazzoccanti, G.; Bigogno, C.; Dondio, G.; Scio, P.; Coluccia, A.; Fracella, M.; Antonelli, G.; Lembo, D.; Tramontano, Enzo; Silvestri, R.; Mastrangelo, E.; La Regina, G. | ACS INFECTIOUS DISEASES | - |
| Call for Papers: Infectious Diseases Research in the Global South: Treatments and Treatment Failures | 1-Jan-2024 | Corona, Angela; Ganesan, Sandhya; Matange, Nishad; Wicht, Kathryn | ACS INFECTIOUS DISEASES | - |
| Structure-Based Design of Novel Thiazolone[3,2-a]pyrimidine Derivatives as Potent RNase H Inhibitors for HIV Therapy | 1-Jan-2024 | Zhu, X. -D.; Corona, A.; Maloccu, S.; Tramontano, E.; Wang, S.; Pannecouque, C.; De Clercq, E.; Meng, G.; Chen, F. -E. | MOLECULES | - |
| Design, synthesis and biological evaluation of Thiazolo[3, 2-a]Pyrimidine derivatives as novel RNase H inhibitors | 1-Jan-2024 | Zhao, K. -X.; Zhang, Y. -Y.; Wang, J. -S.; Wang, S.; Corona, A.; Maloccu, S.; Tramontano, E.; Pannecouque, C.; De Clercq, E.; Meng, G.; Wang, L.; Chen, F. -E. | BIOORGANIC CHEMISTRY | - |
| Expanding the Solvent/Protein Region Occupation of the Non-Nucleoside Reverse Transcriptase Inhibitor Binding Pocket for Improved Broad-Spectrum Anti-HIV-1 Efficacy: from Rigid Phenyl-Diarylpyrimidines to Flexible Hydrophilic Piperidine-Diarylpyrimidines | 1-Jan-2024 | Huang, Wen-Juan; Pannecouque, Christophe; De Clercq, Erik; Corona, Angela; Maloccu, Stefania; Tramontano, Enzo; Wang, Shuai; Chen, Fen-Er | JOURNAL OF MEDICINAL CHEMISTRY | - |
| Drug repurposing screen to identify inhibitors of the RNA polymerase (nsp12) and helicase (nsp13) from SARS-CoV-2 replication and transcription complex | 1-Jan-2024 | Kuzikov, Maria; Reinshagen, Jeanette; Wycisk, Krzysztof; Corona, Angela; Esposito, Francesca; Malune, Paolo; Manelfi, Candida; Iaconis, Daniela; Beccari, Andrea; Tramontano, Enzo; Nowotny, Marcin; Windshügel, Bjorn; Gribbon, Philip; Zaliani, Andrea | VIRUS RESEARCH | - |
| Identification of new benzofuran derivatives as STING agonists with broad-spectrum antiviral activity | 1-Jan-2024 | Paulis, A.; Onali, A.; Vidalain, P. O.; Lotteau, V.; Jaquemin, C.; Corona, A.; Distinto, S.; Delogu, G. L.; Tramontano, E. | VIRUS RESEARCH | - |
| Broad-spectrum coronavirus 3C-like protease peptidomimetic inhibitors effectively block SARS-CoV-2 replication in cells: Design, synthesis, biological evaluation, and X-ray structure determination | 1-Jan-2023 | Stefanelli, Irina; Corona, Angela; Cerchia, Carmen; Cassese, Emilia; Improta, Salvatore; Costanzi, Elisa; Pelliccia, Sveva; Morasso, Stefano; Esposito, Francesca; Paulis, Annalaura; Scognamiglio, Sante; Di Leva, Francesco Saverio; Storici, Paola; Brindisi, Margherita; Tramontano, Enzo; Cannalire, Rolando; Summa, Vincenzo | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - |
| METODO DI STIMA DI PARAMETRI DI VIRUS IN UN CAMPIONE DI MATERIALE BIOLOGICO | 1-Jan-2023 | Chiriu, Daniele; Tramontano, Enzo; Corona, Angela; Carbonaro, Carlo Maria; David, Tullia Carla; Porcu, Stefania; Ricci, Pier Carlo | - | - |
| Versatile anti-infective properties of pyrido- and dihydropyrido[2,3-d]pyrimidine-based compounds | 1-Jan-2023 | Al Nasr, Ibrahim S; Corona, Angela; Koko, Waleed S; Khan, Tariq A; Ben Said, Ridha; Daoud, Ismail; Rahali, Seyfeddine; Tramontano, Enzo; Schobert, Rainer; Amdouni, Noureddine; Biersack, Bernhard | BIOORGANIC & MEDICINAL CHEMISTRY | - |
| Targeting SARS-CoV-2 Main Protease: A Successful Story Guided by an In Silico Drug Repurposing Approach | 1-Jan-2023 | Alessandra Ambrosio, Francesca; Costa, Giosuè; Romeo, Isabella; Esposito, Francesca; Alkhatib, Mohammad; Salpini, Romina; Svicher, Valentina; Corona, Angela; Malune, Paolo; Tramontano, Enzo; Ceccherini-Silberstein, Francesca; Alcaro, Stefano; Anna Artese, And | JOURNAL OF CHEMICAL INFORMATION AND MODELING | - |
| DHFR Inhibitors Display a Pleiotropic Anti-Viral Activity against SARS-CoV-2: Insights into the Mechanisms of Action | 1-Jan-2023 | Iaconis, Daniela; Caccuri, Francesca; Manelfi, Candida; Talarico, Carmine; Bugatti, Antonella; Filippini, Federica; Zani, Alberto; Novelli, Rubina; Kuzikov, Maria; Ellinger, Bernhard; Gribbon, Philip; Riecken, Kristoffer; Esposito, Francesca; Corona, Angela; Tramontano, Enzo; Beccari, Andrea Rosario; Caruso, Arnaldo; Allegretti, Marcello | VIRUSES | - |
| Visible Light-Mediated Inactivation of H1N1 Virus UsingPolymer-Based Heterojunction Photocatalyst | 1-Jan-2023 | Porcu, Stefania; Maloccu, Stefania; Corona, Angela; Hazra, Moulika; David, TULLIA CARLA; Chiriu, Daniele; Carbonaro, CARLO MARIA; Tramontano, Enzo; Ricci, PIER CARLO | POLYMERS | - |
| Suramin inhibits SARS-CoV-2 nucleocapsid phosphoprotein genome packaging function | 1-Jan-2023 | Boniardi, Irene; Corona, Angela; Basquin, Jerome; Basquin, Claire; Milia, Jessica; Nagy, István; Tramontano, Enzo; Zinzula, Luca | VIRUS RESEARCH | - |
| 5-Nitro-3-(2-(4-phenylthiazol-2-yl)hydrazineylidene)indolin-2-one derivatives inhibit HIV-1 replication by a multitarget mechanism of action | 1-Jan-2023 | Corona, A.; Meleddu, R.; Delelis, O.; Subra, F.; Cottiglia, F.; Esposito, F.; Distinto, S.; Maccioni, E.; Tramontano, E. | FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | - |
| HIV-1 Integrase Inhibition Activity by Spiroketals Derived from Plagius flosculosus, an Endemic Plant of Sardinia (Italy) and Corsica (France) | 1-Jan-2023 | Sanna, Cinzia; D’Abrosca, Brigida; Fiorentino, Antonio; Giammarino, Federica; Vicenti, Ilaria; Corona, Angela; Caredda, Alessia; Tramontano, Enzo; Esposito, Francesca | PHARMACEUTICALS | - |
| Analogs of the Catechol Derivative Dynasore Inhibit HIV-1 Ribonuclease H, SARS-CoV-2 nsp14 Exoribonuclease, and Virus Replication | 1-Jan-2023 | Asthana, A.; Corona, A.; Shin, W. -J.; Kwak, M. -J.; Gaughan, C.; Tramontano, E.; Jung, J. U.; Schobert, R.; Jha, B. K.; Silverman, R. H.; Biersack, B. | VIRUSES | - |
| Editorial: Viruses, innate immunity, and antiviral strategies: from basic research to clinical applications | 1-Jan-2023 | Fanunza, Elisa; Corona, Angela | FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | - |
| Naïve antibody library derived monoclonal antibody against VP35 of Ebola virus | 1-Jan-2023 | Lai, Jing Yi; Corona, Angela; Ng, Chong Lee; Tramontano, Enzo; Choong, Yee Siew; Lim, Theam Soon | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | - |
| Diketo acid inhibitors of nsp13 of SARS-CoV-2 block viral replication | 1-Jan-2023 | Corona, Angela; Madia, Valentina Noemi; De Santis, Riccardo; Manelfi, Candida; Emmolo, Roberta; Ialongo, Davide; Patacchini, Elisa; Messore, Antonella; Amatore, Donatella; Faggioni, Giovanni; Artico, Marco; Iaconis, Daniela; Talarico, Carmine; Di Santo, Roberto; Lista, Florigio; Costi, Roberta; Tramontano, Enzo | ANTIVIRAL RESEARCH | - |
| Ebola virus disease: In vivo protection provided by the PAMP restricted TLR3 agonist rintatolimod and its mechanism of action | 1-Jan-2023 | Corona, Angela; Strayer, David; Distinto, Simona; Daino, Gian Luca; Paulis, Annalaura; Tramontano, Enzo; Mitchell, William M | ANTIVIRAL RESEARCH | - |
| Discovery of 2-Phenylquinolines with Broad-Spectrum Anti-coronavirus Activity | 1-Jan-2022 | Nizi, Maria Giulia; Persoons, Leentje; Corona, Angela; Felicetti, Tommaso; Cernicchi, Giada; Massari, Serena; Manfroni, Giuseppe; Vangeel, Laura; Barreca, Maria Letizia; Esposito, Francesca; Jochmans, Dirk; Milia, Jessica; Cecchetti, Violetta; Schols, Dominique; Neyts, Johan; Tramontano, Enzo; Sabatini, Stefano; De Jonghe, Steven; Tabarrini, Oriana | ACS MEDICINAL CHEMISTRY LETTERS | - |
| Cytopathic SARS-CoV-2 screening on VERO-E6 cells in a large-scale repurposing effort | 1-Jan-2022 | Zaliani, Andrea; Vangeel, Laura; Reinshagen, Jeanette; Iaconis, Daniela; Kuzikov, Maria; Keminer, Oliver; Wolf, Markus; Ellinger, Bernhard; Esposito, Francesca; Corona, Angela; Tramontano, Enzo; Manelfi, Candida; Herzog, Katja; Jochmans, Dirk; De Jonghe, Steven; Chiu, Winston; Francken, Thibault; Schepers, Joost; Collard, Caroline; Abbasi, Kayvan; Claussen, Carsten; Summa, Vincenzo; Beccari, Andrea R.; Neyts, Johan; Gribbon, Philip; Leyssen, Pieter | SCIENTIFIC DATA | - |
| Targeting SARS-CoV-2 nsp13 Helicase and Assessment of Druggability Pockets: Identification of Two Potent Inhibitors by a Multi-Site In Silico Drug Repurposing Approach | 1-Jan-2022 | Romeo, Isabella; Ambrosio, Francesca Alessandra; Costa, Giosuè; Corona, Angela; Alkhatib, Mohammad; Salpini, Romina; Lemme, Saverio; Vergni, Davide; Svicher, Valentina; Santoro, Maria Mercedes; Tramontano, Enzo; Ceccherini-Silberstein, Francesca; Artese, Anna; Alcaro, Stefano | MOLECULES | - |
| Cynarin blocks Ebola virus replication by counteracting VP35 inhibition of interferon-beta production | 1-Jan-2022 | Corona, Angela; Fanunza, Elisa; Salata, Cristiano; Morwitzer, Melody Jane; Distinto, Simona; Zinzula, Luca; Sanna, Cinzia; Frau, Aldo; Daino, Gian Luca; Quartu, Marina; Taglialatela-Scafati, Orazio; Rigano, Daniela; Reid, Stpatrick; Mirazimi, Alì; Tramontano, Enzo | ANTIVIRAL RESEARCH | - |
| Easy access to α-ketoamides as SARS-CoV-2 and MERS Mpro inhibitors via the PADAM oxidation route | 1-Jan-2022 | Pelliccia, Sveva; Cerchia, Carmen; Esposito, Francesca; Cannalire, Rolando; Corona, Angela; Costanzi, Elisa; Kuzikov, Maria; Gribbon, Philip; Zaliani, Andrea; Brindisi, Margherita; Storici, Paola; Tramontano, Enzo; Summa, Vincenzo | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - |
| Mutations in the 3'-PPT Lead to HIV-1 Replication without Integration | 1-Jan-2022 | Richetta, Clémence; Subra, Frédéric; Malet, Isabelle; Leh, Hervé; Charpentier, Charlotte; Corona, Angela; Collin, Gilles; Descamps, Diane; Deprez, Eric; Parissi, Vincent; Calvez, Vincent; Tramontano, Enzo; Marcelin, Anne-Geneviève; Delelis, Olivier | JOURNAL OF VIROLOGY | - |
| Natural Compounds Inhibit SARS-CoV-2 nsp13 Unwinding and ATPase Enzyme Activities | 1-Jan-2022 | Corona, Angela; Wycisk, Krzysztof; Talarico, Carmine; Manelfi, Candida; Milia, Jessica; Cannalire, Rolando; Esposito, Francesca; Gribbon, Philip; Zaliani, Andrea; Iaconis, Daniela; Beccari, Andrea R.; Summa, Vincenzo; Nowotny, Marcin; Tramontano, Enzo | ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE | - |
| Garcinol from Garcinia indica inhibits HIV-1 reverse transcriptase-associated ribonuclease H | 1-Jan-2021 | Corona, Angela; Seibt, Sebastian; Schaller, David; Schobert, Rainer; Volkamer, Andrea; Biersack, Bernhard; Tramontano, Enzo | ARCHIV DER PHARMAZIE | - |
| Inhibitors of Ebolavirus targeting innate immune evasion | 1-Jan-2021 | Paulis, A. L.; Corona, A.; Tramontano, E. | ANNUAL REPORTS IN MEDICINAL CHEMISTRY | - |
| Natural and Nature-Derived Products Targeting Human Coronaviruses | 1-Jan-2021 | Vougogiannopoulou, Konstantina; Corona, Angela; Tramontano, Enzo; Alexis, Michael N.; Skaltsounis, Alexios-Leandros | MOLECULES | - |
| Flavonoids and Acid-Hydrolysis derivatives of Neo-Clerodane diterpenes from Teucrium flavum subsp. glaucum as inhibitors of the HIV-1 reverse transcriptase–associated RNase H function | 1-Jan-2021 | Fois, Benedetta; Corona, Angela; Tramontano, Enzo; Distinto, Simona; Maccioni, Elias; Meleddu, Rita; Caboni, Pierluigi; Floris, Costantino; Cottiglia, Filippo | JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | - |
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