University of Cagliari
Simona Distinto
Chromones as Nonclassical Inhibitors of Carbonic Anhydrase IX and XII Isoforms: Probing Chromone-Based Derivatives
2026-01-01 Sequeira, L.; Distinto, S.; Fernandes, C.; Sanna, E.; Meleddu, R.; Gaspari, M.; Cottiglia, F.; Onali, A.; Angeli, A.; Borges, F.; Uriarte, E.; Alcaro, S.; Supuran, C. T.; Maccioni, E.
Identifying potential allosteric inhibitors of ZIKV NS3pro through a combined computational and biochemical approach
2025-01-01 Demuru, L.; Lupia, A.; Nieddu, S.; Emmolo, R.; Paulis, A.; Esposito, F.; Distinto, S.; Bryant, S. D.; Onali, A.; Sanna, E.; Atzeni, G.; Cottiglia, F.; Grandi, N.; Corona, A.; Tramontano, E.; Maccioni, E.; Meleddu, R.
Synthesis and Evaluation of Thiazolidinone-Isatin Hybrids for Selective Inhibition of Cancer-Related Carbonic Anhydrases
2025-01-01 Onali, A.; Sanna, E.; Lupia, A.; Secci, D.; Atzeni, G.; Demuru, L.; Angeli, A.; Cottiglia, F.; Meleddu, R.; Emmolo, R.; Corona, A.; Maccioni, E.; Supuran, C. T.; Distinto, S.
Tiazolidinoni come agenti antivirali
2025-01-01 Distinto, Simona; Corona, Angela; Sanna, Erica; Tramontano, Enzo; Maccioni, Elias; Scognamiglio, Sante; Onali, Alessia; Cottiglia, Filippo; Meleddu, Rita; Secci, Daniela; Maloccu, Stefania
Exploring the 1-(4-Nitrophenyl)-3-arylprop-2-en-1-one Scaffold for the Selective Inhibition of Monoamine Oxidase B
2024-01-01 Meleddu, Rita; Fais, Antonella; Era, Benedetta; Floris, Sonia; Distinto, Simona; Lupia, Antonio; Cottiglia, Filippo; Onali, Alessia; Sanna, Erica; Secci, Daniela; Atzeni, Giulia; Demuru, Laura; Caboni, Pierluigi; Valenti, Donatella; Maccioni, Elias
Identification of new benzofuran derivatives as STING agonists with broad-spectrum antiviral activity
2024-01-01 Paulis, A.; Onali, A.; Vidalain, P. O.; Lotteau, V.; Jaquemin, C.; Corona, A.; Distinto, S.; Delogu, G. L.; Tramontano, E.
Suppression of lipopolysaccharide-induced COX-2 expression via p38MAPK, JNK, and C/EBPβ phosphorylation inhibition by furomagydarin A, a benzofuran glycoside from Magydaris pastinacea
2024-01-01 Huang, Shiu-Wen; Hsu, Ming Jen; Chen, Hsiu-Chen; Meleddu, Rita; Distinto, Simona; Maccioni, Elias; Cottiglia, Filippo
Privileged Scaffold Hybridization in the Design of Carbonic Anhydrase Inhibitors
2024-01-01 Secci, Daniela; Sanna, Erica; Distinto, Simona; Onali, Alessia; Lupia, Antonio; Demuru, Laura; Atzeni, Giulia; Meleddu, Rita; Cottiglia, Filippo; Angeli, Andrea; Supuran, Claudiu T.; Maccioni, Elias
New Structural Features of Isatin Dihydrothiazole Hybrids for Selective Carbonic Anhydrase Inhibitors
2024-01-01 Secci, Daniela; Distinto, Simona; Onali, Alessia; Sanna, Erica; Lupia, Antonio; Demuru, Laura; Atzeni, Giulia; Cottiglia, Filippo; Meleddu, Rita; Angeli, Andrea; Supuran, Claudiu T.; Maccioni, Elias
5-Nitro-3-(2-(4-phenylthiazol-2-yl)hydrazineylidene)indolin-2-one derivatives inhibit HIV-1 replication by a multitarget mechanism of action
2023-01-01 Corona, A.; Meleddu, R.; Delelis, O.; Subra, F.; Cottiglia, F.; Esposito, F.; Distinto, S.; Maccioni, E.; Tramontano, E.
2H-chromene and 7H-furo-chromene derivatives selectively inhibit tumour associated human carbonic anhydrase IX and XII isoforms
2023-01-01 Sequeira, Lisa; Distinto, Simona; Meleddu, Rita; Gaspari, Marco; Angeli, Andrea; Cottiglia, Filippo; Secci, Daniela; Onali, Alessia; Sanna, Erica; Borges, Fernanda; Uriarte, Eugenio; Alcaro, Stefano; Supuran, Claudiu T.; Maccioni, Elias
Ebola virus disease: In vivo protection provided by the PAMP restricted TLR3 agonist rintatolimod and its mechanism of action
2023-01-01 Corona, Angela; Strayer, David; Distinto, Simona; Daino, Gian Luca; Paulis, Annalaura; Tramontano, Enzo; Mitchell, William M
Cynarin blocks Ebola virus replication by counteracting VP35 inhibition of interferon-beta production
2022-01-01 Corona, Angela; Fanunza, Elisa; Salata, Cristiano; Morwitzer, Melody Jane; Distinto, Simona; Zinzula, Luca; Sanna, Cinzia; Frau, Aldo; Daino, Gian Luca; Quartu, Marina; Taglialatela-Scafati, Orazio; Rigano, Daniela; Reid, Stpatrick; Mirazimi, Alì; Tramontano, Enzo
Selective inhibition of carbonic anhydrase IX and XII by coumarin and psoralen derivatives
2021-01-01 Meleddu, R.; Deplano, S.; Maccioni, E.; Ortuso, F.; Cottiglia, F.; Secci, D.; Onali, A.; Sanna, E.; Angeli, A.; Angius, R.; Alcaro, S.; Supuran, C. T.; Distinto, S.
Flavonoids and Acid-Hydrolysis derivatives of Neo-Clerodane diterpenes from Teucrium flavum subsp. glaucum as inhibitors of the HIV-1 reverse transcriptase–associated RNase H function
2021-01-01 Fois, Benedetta; Corona, Angela; Tramontano, Enzo; Distinto, Simona; Maccioni, Elias; Meleddu, Rita; Caboni, Pierluigi; Floris, Costantino; Cottiglia, Filippo
2-(2-methyl-2-nitrovinyl)furan but not furvina interfere with staphylococcus aureus agr quorum-sensing system and potentiate the action of fusidic acid against biofilms
2021-01-01 Oliveira, D.; Borges, A.; Ruiz, R. M.; Negrin, Z. R.; Distinto, S.; Borges, F.; Simoes, M.
Exploring new scaffolds for the dual inhibition of HIV-1 RT polymerase and ribonuclease associated functions
2021-01-01 Meleddu, Rita; Corona, Angela; Distinto, Simona; Cottiglia, Filippo; Deplano, Serenella; Sequeira, Lisa; Secci, Daniela; Onali, Alessia; Sanna, Erica; Esposito, Francesca; Cirone, Italo; Ortuso, Francesco; Alcaro, Stefano; Tramontano, Enzo; Mátyus, Péter; Maccioni, Elias
Targeting HIV-1 RNase H: N'-(2-Hydroxy-benzylidene)-3,4,5-Trihydroxybenzoylhydrazone as Selective Inhibitor Active against NNRTIs-Resistant Variants
2020-01-01 Corona, Angela; Ballana, Ester; Distinto, Simona; Rogolino, Dominga; Del Vecchio, Claudia; Carcelli, Mauro; Badia, Roger; Riveira-Muñoz, Eva; Esposito, Francesca; Parolin, Cristina; Esté, José A; Grandi, Nicole; Tramontano, Enzo
Quercetin blocks Ebola Virus infection by counteracting the VP24 Interferon inhibitory function
2020-01-01 Fanunza, Elisa; Iampietro, Mathieu; Distinto, Simona; Corona, Angela; Quartu, Marina; Maccioni, Elias; Horvat, Branka; Tramontano, Enzo
Coumarins from Magydaris pastinacea as inhibitors of the tumour-associated carbonic anhydrases IX and XII: isolation, biological studies and in silico evaluation
2020-01-01 Fois, B.; Distinto, S.; Meleddu, R.; Deplano, S.; Maccioni, E.; Floris, C.; Rosa, A.; Nieddu, M.; Caboni, P.; Sissi, C.; Angeli, A.; Supuran, C. T.; Cottiglia, F.
New Dihydrothiazole Benzensulfonamides: Looking for Selectivity toward Carbonic Anhydrase Isoforms I, II, IX, and XII
2020-01-01 Meleddu, R.; Distinto, S.; Cottiglia, F.; Angius, R.; Caboni, P.; Angeli, A.; Melis, C.; Deplano, S.; Alcaro, S.; Ortuso, F.; Supuran, C. T.; Maccioni, E.
Novel natural non-nucleoside inhibitors of HIV-1 reverse transcriptase identified by shape- and structure-based virtual screening techniques
2019-01-01 Costa, Giosuè; Rocca, Roberta; Corona, Angela; Grandi, Nicole; Moraca, Federica; Romeo, Isabella; Talarico, Carmine; Giovanna Gagliardi, Maria; Alessandra Ambrosio, Francesca; Ortuso, Francesco; Alcaro, Stefano; Distinto, Simona; Maccioni, Elias; Tramontano, Enzo; Artese, Anna
Ferulic Acid Esters and Withanolides: in Search of Withania somnifera GABAA Receptor Modulators
2019-01-01 Sonar, Vijay P.; Fois, Benedetta; Distinto, Simona; Maccioni, Elias; Meleddu, Rita; Cottiglia, Filippo; Acquas, ELIO MARIA GIOACCHINO; Kasture, Sanjay; Floris, Costantino; Colombo, Daniele; Sissi, Claudia; Sanna, Enrico; Talani, Giuseppe
From cycloheptathiophene-3-carboxamide to oxazinone-based derivatives as allosteric HIV-1 ribonuclease H inhibitors
2019-01-01 Massari, Serena; Corona, Angela; Distinto, Simona; Desantis, Jenny; Caredda, Alessia; Sabatini, Stefano; Manfroni, Giuseppe; Felicetti, Tommaso; Cecchetti, Violetta; Pannecouque, Christophe; Maccioni, Elias; Tramontano, Enzo; Tabarrini, Oriana
Exploring new structural features of the 4-[(3-methyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzenesulphonamide scaffold for the inhibition of human carbonic anhydrases
2019-01-01 Distinto, S.; Meleddu, R.; Ortuso, F.; Cottiglia, F.; Deplano, S.; SOUSA SEQUEIRA, ANA LISA; Melis, C.; Fois, B.; Angeli, A.; Capasso, C.; Angius, Riccardo; Alcaro, S.; Supuran, C. T.; Maccioni, E.
Investigating the Anticancer Activity of Isatin/Dihydropyrazole Hybrids
2019-01-01 Meleddu, Rita; Petrikaite, Vilma; Distinto, Simona; Arridu, Antonella; Angius, Rossella; Serusi, Lorenzo; Škarnulytė, Laura; Endriulaitytė, Ugnė; Paškevičiu̅tė, Miglė; Cottiglia, Filippo; Gaspari, Marco; Taverna, Domenico; Deplano, Serenella; Fois, Benedetta; Maccioni, Elias
Targeting tumor associated carbonic anhydrase IX and XII: Highly isozyme selective coumarin and psoralen inhibitors
2018-01-01 Melis, Claudia; Distinto, Simona; Bianco, Giulia; Meleddu, Rita; Cottiglia, Filippo; Fois, Benedetta; Taverna, Domenico; Angius, Rossella; Alcaro, Stefano; Ortuso, Francesco; Gaspari, Marco; Angeli, Andrea; Del Prete, Sonia; Capasso, Clemente; Supuran, Claudiu T.; Maccioni, Elias
Identification of Myricetin as Ebolavirus VP35-dsRNA interaction inhibitor through a novel fluorescence-based assay
2018-01-01 Luca Daino, Gian; Frau, Aldo; Sanna, Cinzia; Rigano, Daniela; Distinto, Simona; Madau, Veronica; Esposito, Francesca; Fanunza, Elisa; Bianco, Giulia; Taglialatela-Scafati, Orazio; Zinzula, Luca; Maccioni, Elias; Corona, Angela; Tramontano, Enzo
Tuning the Dual Inhibition of Carbonic Anhydrase and Cyclooxygenase by Dihydrothiazole Benzensulfonamides
2018-01-01 Meleddu, Rita; Distinto, Simona; Cottiglia, Filippo; Angius, Rossella; Gaspari, Marco; Taverna, Domenico; Melis, Claudia; Angeli, Andrea; Bianco, Giulia; Deplano, Serenella; Fois, Benedetta; Del Prete, Sonia; Capasso, Clemente; Alcaro, Stefano; Ortuso, Francesco; Yanez, Matilde; Supuran Claudiu, T.; Maccioni, Elias
N-Acylbenzenesulfonamide dihydro-1,3,4-oxadiazole hybrids: seeking selectivity toward carbonic anhydrase isoforms
2017-01-01 Bianco, Giulia; Meleddu, Rita; Distinto, Simona; Cottiglia, Filippo; Gaspari, Marco; Melis, Claudia; Corona, Angela; Angius, Rossella; Angeli, Andrea; Taverna, Domenico; Alcaro, Stefano; Leitans, Janis; Kazaks, Andris; Tars, Kaspars; Supuran, Claudiu T.; Maccioni, Elias
Multi-target activity of Hemidesmus indicus decoction against innovative HIV-1 drug targets and characterization of Lupeol mode of action
2017-01-01 Esposito, Francesca; Mandrone, Manuela; Del Vecchio, Claudia; Carli, Ilaria; Distinto, Simona; Corona, Angela; Lianza, Mariacaterina; Piano, Dario; Tacchini, Massimo; Maccioni, Elias; Cottiglia, Filippo; Saccon, Elisa; Poli, Ferruccio; Parolin, Cristina; Tramontano, Enzo
Natural product-inspired esters and amides of ferulic and caffeic acid as dual inhibitors of HIV-1 reverse transcriptase
2017-01-01 Sonar, VIJAY PRAKASH; Corona, Angela; Distinto, Simona; Maccioni, Elias; Meleddu, Rita; Fois, Benedetta; Floris, Costantino; Malpure, Nilesh V.; Alcaro, Stefano; Tramontano, Enzo; Cottiglia, Filippo
Design, synthesis and antiviral evaluation of novel heteroarylcarbothioamide derivatives as dual inhibitors of HIV-1 Reverse transcriptase-associated RNase H and RDDP functions
2017-01-01 Corona, Angela; Onnis, Valentina; Deplano, Alessandro; Bianco, Giulia; Demurtas, Monica; Distinto, Simona; Cheng, Yung Chi; Alcaro, Stefano; Esposito, Francesca; Tramontano, Enzo
Isatin thiazoline hybrids as dual inhibitors of HIV-1 reverse transcriptase
2017-01-01 Meleddu, Rita; Distinto, Simona; Corona, Angela; Tramontano, Enzo; Bianco, Giulia; Melis, Claudia; Cottiglia, Filippo; Maccioni, Elias
Through scaffold modification to 3,5-diaryl-4,5-dihydroisoxazoles: new potent and selective inhibitors of monoamine oxidase B
2017-01-01 Meleddu, Rita; Distinto, Simona; Cirilli, Roberto; Alcaro, Stefano; Yanez, Matilde; Sanna, MARIA LUISA; Corona, Angela; Melis, Claudia; Bianco, Giulia; Matyus, Peter; Cottiglia, Filippo; Maccioni, Elias
Isatin: a privileged scaffold for the design of carbonic anhydrase inhibitors
2017-01-01 Melis, Claudia; Meleddu, Rita; Angeli, Andrea; Distinto, Simona; Bianco, Giulia; Capasso, Clemente; Cottiglia, Filippo; Angius, Rossella; Supuran, Claudiu T.; Maccioni, Elias
Phenylpropenoids from Bupleurum fruticosum as Anti-Human Rhinovirus Species A Selective Capsid Binders
2017-01-01 Fois, Benedetta; Bianco, Giulia; Sonar, Vijay P.; Distinto, Simona; Maccioni, Elias; Meleddu, Rita; Melis, Claudia; Marras, Luisa; Pompei, Raffaello; Floris, Costantino; Caboni, Pierluigi; Cottiglia, Filippo
Identification of G-quadruplex DNA/RNA binders: Structure-based virtual screening and biophysical characterization
2017-01-01 Rocca, R.; Moraca, F.; Costa, G.; Nadai, M.; Scalabrin, M.; Talarico, C.; Distinto, S.; Maccioni, E.; Ortuso, F.; Artese, A.; Alcaro, S.; Richter, S. N.
Exploring the thiazole scaffold for the identification of new agents for the treatment of fluconazole resistant Candida
2016-01-01 Meleddu, Rita; Distinto, Simona; Corona, Angela; Maccioni, Elias; Arridu, Antonella; Melis, Claudia; Bianco, Giulia; Matyus, Peter; Cottiglia, Filippo; Sanna, Adriana; DE LOGU, Alessandro
Drug design, synthesis, in vitro and in silico evaluation of selective monoaminoxidase B inhibitors based on 3-acetyl-2-dichlorophenyl-5-aryl-2,3-dihydro-1,3,4-oxadiazole chemical scaffold
2016-01-01 Distinto, Simona; Meleddu, Rita; Yanez, Matilde; Cirilli, Roberto; Bianco, Giulia; Sanna, MARIA LUISA; Arridu, Antonella; Cossu, Pietro; Cottiglia, Filippo; Faggi, Cristina; Ortuso, Francesco; Alcaro, Stefano; Maccioni, Elias
Hit Identification of a Novel Dual Binder for h-telo/c-myc G-Quadruplex by a Combination of Pharmacophore Structure-Based Virtual Screening and Docking Refinement
2016-01-01 Rocca, Roberta; Costa, Giosuè; Artese, Anna; Parrotta, Lucia; Ortuso, Francesco; Maccioni, Elias; Pinato, Odra; Greco, Maria Laura; Sissi, Claudia; Alcaro, Stefano; Distinto, Simona; Moraca, Federica
Ribonuclease H/DNA polymerase HIV-1 reverse transcriptase dual inhibitor: mechanistic studies on the allosteric mode of action of isatin-based compound RMNC6
2016-01-01 Corona, Angela; Meleddu, Rita; Esposito, Francesca; Distinto, Simona; Bianco, Giulia; Masaoka, T; Maccioni, Elias; Menéndez Arias, L; Alcaro, S; Le Grice, Sfj; Tramontano, Enzo
Studies on Cycloheptathiophene-3-carboxamide Derivatives as Allosteric HIV-1 Ribonuclease H Inhibitors
2016-01-01 Corona, Angela; Desantis, Jenny; Massari, Serena; Distinto, Simona; Masaoka, Takashi; Sabatini, Stefano; Esposito, Francesca; Manfroni, Giuseppe; Maccioni, Elias; Cecchetti, Violetta; Pannecouque, Christophe; Le Grice, Stuart F. J; Tramontano, Enzo; Tabarrini, Oriana
Sennoside A, derived from the traditional chinese medicine plant Rheum L., is a new dual HIV-1 inhibitor effective on HIV-1 replication
2016-01-01 Esposito, Francesca; Carli, Ilaria; Del Vecchio, Claudia; Xu, Lijia; Corona, Angela; Grandi, Nicole; Piano, Dario; Maccioni, Elias; Distinto, Simona; Parolin, Cristina; Tramontano, Enzo
Methoxyflavones from Stachys glutinosa with binding affinity to opioid receptors: in silico, in vitro, and in vivo studies
2015-01-01 Ruiu, S; Anzani, N; Orrù, A; Floris, Costantino; Caboni, Pierluigi; Alcaro, S; Maccioni, Elias; Distinto, Simona; Cottiglia, Filippo
New 4-[(3-cyclohexyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzene-1-sulfonamides, synthesis and inhibitory activity toward carbonic anhydrase I, II, IX, XII
2015-01-01 Meleddu, Rita; Maccioni, Elias; Distinto, Simona; Bianco, Giulia; Melis, Claudia; Alcaro, Stefano; Cottiglia, Filippo; Ceruso, Mariangela; Supuran, Claudiu T.
(3Z)-3-(2-[4-(aryl)-1,3-thiazol-2-yl]hydrazin-1-ylidene)-2,3-dihydro- 1H -indol-2-one derivatives as dual inhibitors of HIV-1 reverse transcriptase
2015-01-01 Meleddu, Rita; Distinto, Simona; Corona, Angela; Bianco, Giulia; Cannas, Valeria; Esposito, Francesca; Artese, A; Alcaro, S; Matyus, P; Bogdan, D; Cottiglia, Filippo; Tramontano, Enzo; Maccioni, Elias
Structure-based virtual screening of novel natural alkaloid derivatives as potential binders of h-telo and c-myc DNA G-quadruplex conformations
2015-01-01 Rocca, R.; Moraca, F.; Costa, G.; Alcaro, S.; Distinto, Simona; Maccioni, Elias; Ortuso, F.; Artese, A.; Parrotta, L.
Site directed mutagenesis studies on HIV-1 reverse transcriptase (RT) enlighten the mechanism of action of a new Ribonuclease H/DNA polymerase RT dual inhibitor
2014-01-01 Esposito, Francesca; Corona, Angela; Meleddu, Rita; Distinto, Simona; Giulia, Bianco; Maccioni, Elias; Stuart JF Le Grice, ; Enzo, Tramontano
2-methoxynaphthalen thiazole derivate : a new HIV-1 RT Ribonuclease H/DNA polymerase dual inhibitor active on viral replication
2014-01-01 Corona, Angela; Meleddu, R.; Esposito, E.; Distinto, S.; Bianco, G.; Maccioni, E.; Tramontano, E. .
| Title | Issue Date | Author(s) | Journal | Publisher |
|---|---|---|---|---|
| Chromones as Nonclassical Inhibitors of Carbonic Anhydrase IX and XII Isoforms: Probing Chromone-Based Derivatives | 1-Jan-2026 | Sequeira, L.; Distinto, S.; Fernandes, C.; Sanna, E.; Meleddu, R.; Gaspari, M.; Cottiglia, F.; Onali, A.; Angeli, A.; Borges, F.; Uriarte, E.; Alcaro, S.; Supuran, C. T.; Maccioni, E. | ARCHIV DER PHARMAZIE | - |
| Identifying potential allosteric inhibitors of ZIKV NS3pro through a combined computational and biochemical approach | 1-Jan-2025 | Demuru, L.; Lupia, A.; Nieddu, S.; Emmolo, R.; Paulis, A.; Esposito, F.; Distinto, S.; Bryant, S. D.; Onali, A.; Sanna, E.; Atzeni, G.; Cottiglia, F.; Grandi, N.; Corona, A.; Tramontano, E.; Maccioni, E.; Meleddu, R. | - | - |
| Synthesis and Evaluation of Thiazolidinone-Isatin Hybrids for Selective Inhibition of Cancer-Related Carbonic Anhydrases | 1-Jan-2025 | Onali, A.; Sanna, E.; Lupia, A.; Secci, D.; Atzeni, G.; Demuru, L.; Angeli, A.; Cottiglia, F.; Meleddu, R.; Emmolo, R.; Corona, A.; Maccioni, E.; Supuran, C. T.; Distinto, S. | ACS MEDICINAL CHEMISTRY LETTERS | - |
| Tiazolidinoni come agenti antivirali | 1-Jan-2025 | Distinto, Simona; Corona, Angela; Sanna, Erica; Tramontano, Enzo; Maccioni, Elias; Scognamiglio, Sante; Onali, Alessia; Cottiglia, Filippo; Meleddu, Rita; Secci, Daniela; Maloccu, Stefania | - | - |
| Exploring the 1-(4-Nitrophenyl)-3-arylprop-2-en-1-one Scaffold for the Selective Inhibition of Monoamine Oxidase B | 1-Jan-2024 | Meleddu, Rita; Fais, Antonella; Era, Benedetta; Floris, Sonia; Distinto, Simona; Lupia, Antonio; Cottiglia, Filippo; Onali, Alessia; Sanna, Erica; Secci, Daniela; Atzeni, Giulia; Demuru, Laura; Caboni, Pierluigi; Valenti, Donatella; Maccioni, Elias | ACS MEDICINAL CHEMISTRY LETTERS | - |
| Identification of new benzofuran derivatives as STING agonists with broad-spectrum antiviral activity | 1-Jan-2024 | Paulis, A.; Onali, A.; Vidalain, P. O.; Lotteau, V.; Jaquemin, C.; Corona, A.; Distinto, S.; Delogu, G. L.; Tramontano, E. | VIRUS RESEARCH | - |
| Suppression of lipopolysaccharide-induced COX-2 expression via p38MAPK, JNK, and C/EBPβ phosphorylation inhibition by furomagydarin A, a benzofuran glycoside from Magydaris pastinacea | 1-Jan-2024 | Huang, Shiu-Wen; Hsu, Ming Jen; Chen, Hsiu-Chen; Meleddu, Rita; Distinto, Simona; Maccioni, Elias; Cottiglia, Filippo | JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | - |
| Privileged Scaffold Hybridization in the Design of Carbonic Anhydrase Inhibitors | 1-Jan-2024 | Secci, Daniela; Sanna, Erica; Distinto, Simona; Onali, Alessia; Lupia, Antonio; Demuru, Laura; Atzeni, Giulia; Meleddu, Rita; Cottiglia, Filippo; Angeli, Andrea; Supuran, Claudiu T.; Maccioni, Elias | MOLECULES | - |
| New Structural Features of Isatin Dihydrothiazole Hybrids for Selective Carbonic Anhydrase Inhibitors | 1-Jan-2024 | Secci, Daniela; Distinto, Simona; Onali, Alessia; Sanna, Erica; Lupia, Antonio; Demuru, Laura; Atzeni, Giulia; Cottiglia, Filippo; Meleddu, Rita; Angeli, Andrea; Supuran, Claudiu T.; Maccioni, Elias | ACS MEDICINAL CHEMISTRY LETTERS | - |
| 5-Nitro-3-(2-(4-phenylthiazol-2-yl)hydrazineylidene)indolin-2-one derivatives inhibit HIV-1 replication by a multitarget mechanism of action | 1-Jan-2023 | Corona, A.; Meleddu, R.; Delelis, O.; Subra, F.; Cottiglia, F.; Esposito, F.; Distinto, S.; Maccioni, E.; Tramontano, E. | FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | - |
| 2H-chromene and 7H-furo-chromene derivatives selectively inhibit tumour associated human carbonic anhydrase IX and XII isoforms | 1-Jan-2023 | Sequeira, Lisa; Distinto, Simona; Meleddu, Rita; Gaspari, Marco; Angeli, Andrea; Cottiglia, Filippo; Secci, Daniela; Onali, Alessia; Sanna, Erica; Borges, Fernanda; Uriarte, Eugenio; Alcaro, Stefano; Supuran, Claudiu T.; Maccioni, Elias | JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | - |
| Ebola virus disease: In vivo protection provided by the PAMP restricted TLR3 agonist rintatolimod and its mechanism of action | 1-Jan-2023 | Corona, Angela; Strayer, David; Distinto, Simona; Daino, Gian Luca; Paulis, Annalaura; Tramontano, Enzo; Mitchell, William M | ANTIVIRAL RESEARCH | - |
| Cynarin blocks Ebola virus replication by counteracting VP35 inhibition of interferon-beta production | 1-Jan-2022 | Corona, Angela; Fanunza, Elisa; Salata, Cristiano; Morwitzer, Melody Jane; Distinto, Simona; Zinzula, Luca; Sanna, Cinzia; Frau, Aldo; Daino, Gian Luca; Quartu, Marina; Taglialatela-Scafati, Orazio; Rigano, Daniela; Reid, Stpatrick; Mirazimi, Alì; Tramontano, Enzo | ANTIVIRAL RESEARCH | - |
| Selective inhibition of carbonic anhydrase IX and XII by coumarin and psoralen derivatives | 1-Jan-2021 | Meleddu, R.; Deplano, S.; Maccioni, E.; Ortuso, F.; Cottiglia, F.; Secci, D.; Onali, A.; Sanna, E.; Angeli, A.; Angius, R.; Alcaro, S.; Supuran, C. T.; Distinto, S. | JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | - |
| Flavonoids and Acid-Hydrolysis derivatives of Neo-Clerodane diterpenes from Teucrium flavum subsp. glaucum as inhibitors of the HIV-1 reverse transcriptase–associated RNase H function | 1-Jan-2021 | Fois, Benedetta; Corona, Angela; Tramontano, Enzo; Distinto, Simona; Maccioni, Elias; Meleddu, Rita; Caboni, Pierluigi; Floris, Costantino; Cottiglia, Filippo | JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | - |
| 2-(2-methyl-2-nitrovinyl)furan but not furvina interfere with staphylococcus aureus agr quorum-sensing system and potentiate the action of fusidic acid against biofilms | 1-Jan-2021 | Oliveira, D.; Borges, A.; Ruiz, R. M.; Negrin, Z. R.; Distinto, S.; Borges, F.; Simoes, M. | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
| Exploring new scaffolds for the dual inhibition of HIV-1 RT polymerase and ribonuclease associated functions | 1-Jan-2021 | Meleddu, Rita; Corona, Angela; Distinto, Simona; Cottiglia, Filippo; Deplano, Serenella; Sequeira, Lisa; Secci, Daniela; Onali, Alessia; Sanna, Erica; Esposito, Francesca; Cirone, Italo; Ortuso, Francesco; Alcaro, Stefano; Tramontano, Enzo; Mátyus, Péter; Maccioni, Elias | MOLECULES | - |
| Targeting HIV-1 RNase H: N'-(2-Hydroxy-benzylidene)-3,4,5-Trihydroxybenzoylhydrazone as Selective Inhibitor Active against NNRTIs-Resistant Variants | 1-Jan-2020 | Corona, Angela; Ballana, Ester; Distinto, Simona; Rogolino, Dominga; Del Vecchio, Claudia; Carcelli, Mauro; Badia, Roger; Riveira-Muñoz, Eva; Esposito, Francesca; Parolin, Cristina; Esté, José A; Grandi, Nicole; Tramontano, Enzo | VIRUSES | - |
| Quercetin blocks Ebola Virus infection by counteracting the VP24 Interferon inhibitory function | 1-Jan-2020 | Fanunza, Elisa; Iampietro, Mathieu; Distinto, Simona; Corona, Angela; Quartu, Marina; Maccioni, Elias; Horvat, Branka; Tramontano, Enzo | ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | - |
| Coumarins from Magydaris pastinacea as inhibitors of the tumour-associated carbonic anhydrases IX and XII: isolation, biological studies and in silico evaluation | 1-Jan-2020 | Fois, B.; Distinto, S.; Meleddu, R.; Deplano, S.; Maccioni, E.; Floris, C.; Rosa, A.; Nieddu, M.; Caboni, P.; Sissi, C.; Angeli, A.; Supuran, C. T.; Cottiglia, F. | JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | - |
| New Dihydrothiazole Benzensulfonamides: Looking for Selectivity toward Carbonic Anhydrase Isoforms I, II, IX, and XII | 1-Jan-2020 | Meleddu, R.; Distinto, S.; Cottiglia, F.; Angius, R.; Caboni, P.; Angeli, A.; Melis, C.; Deplano, S.; Alcaro, S.; Ortuso, F.; Supuran, C. T.; Maccioni, E. | ACS MEDICINAL CHEMISTRY LETTERS | - |
| Novel natural non-nucleoside inhibitors of HIV-1 reverse transcriptase identified by shape- and structure-based virtual screening techniques | 1-Jan-2019 | Costa, Giosuè; Rocca, Roberta; Corona, Angela; Grandi, Nicole; Moraca, Federica; Romeo, Isabella; Talarico, Carmine; Giovanna Gagliardi, Maria; Alessandra Ambrosio, Francesca; Ortuso, Francesco; Alcaro, Stefano; Distinto, Simona; Maccioni, Elias; Tramontano, Enzo; Artese, Anna | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - |
| Ferulic Acid Esters and Withanolides: in Search of Withania somnifera GABAA Receptor Modulators | 1-Jan-2019 | Sonar, Vijay P.; Fois, Benedetta; Distinto, Simona; Maccioni, Elias; Meleddu, Rita; Cottiglia, Filippo; Acquas, ELIO MARIA GIOACCHINO; Kasture, Sanjay; Floris, Costantino; Colombo, Daniele; Sissi, Claudia; Sanna, Enrico; Talani, Giuseppe | JOURNAL OF NATURAL PRODUCTS | - |
| From cycloheptathiophene-3-carboxamide to oxazinone-based derivatives as allosteric HIV-1 ribonuclease H inhibitors | 1-Jan-2019 | Massari, Serena; Corona, Angela; Distinto, Simona; Desantis, Jenny; Caredda, Alessia; Sabatini, Stefano; Manfroni, Giuseppe; Felicetti, Tommaso; Cecchetti, Violetta; Pannecouque, Christophe; Maccioni, Elias; Tramontano, Enzo; Tabarrini, Oriana | JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | - |
| Exploring new structural features of the 4-[(3-methyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzenesulphonamide scaffold for the inhibition of human carbonic anhydrases | 1-Jan-2019 | Distinto, S.; Meleddu, R.; Ortuso, F.; Cottiglia, F.; Deplano, S.; SOUSA SEQUEIRA, ANA LISA; Melis, C.; Fois, B.; Angeli, A.; Capasso, C.; Angius, Riccardo; Alcaro, S.; Supuran, C. T.; Maccioni, E. | JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | - |
| Investigating the Anticancer Activity of Isatin/Dihydropyrazole Hybrids | 1-Jan-2019 | Meleddu, Rita; Petrikaite, Vilma; Distinto, Simona; Arridu, Antonella; Angius, Rossella; Serusi, Lorenzo; Škarnulytė, Laura; Endriulaitytė, Ugnė; Paškevičiu̅tė, Miglė; Cottiglia, Filippo; Gaspari, Marco; Taverna, Domenico; Deplano, Serenella; Fois, Benedetta; Maccioni, Elias | ACS MEDICINAL CHEMISTRY LETTERS | - |
| Targeting tumor associated carbonic anhydrase IX and XII: Highly isozyme selective coumarin and psoralen inhibitors | 1-Jan-2018 | Melis, Claudia; Distinto, Simona; Bianco, Giulia; Meleddu, Rita; Cottiglia, Filippo; Fois, Benedetta; Taverna, Domenico; Angius, Rossella; Alcaro, Stefano; Ortuso, Francesco; Gaspari, Marco; Angeli, Andrea; Del Prete, Sonia; Capasso, Clemente; Supuran, Claudiu T.; Maccioni, Elias | ACS MEDICINAL CHEMISTRY LETTERS | - |
| Identification of Myricetin as Ebolavirus VP35-dsRNA interaction inhibitor through a novel fluorescence-based assay | 1-Jan-2018 | Luca Daino, Gian; Frau, Aldo; Sanna, Cinzia; Rigano, Daniela; Distinto, Simona; Madau, Veronica; Esposito, Francesca; Fanunza, Elisa; Bianco, Giulia; Taglialatela-Scafati, Orazio; Zinzula, Luca; Maccioni, Elias; Corona, Angela; Tramontano, Enzo | BIOCHEMISTRY | - |
| Tuning the Dual Inhibition of Carbonic Anhydrase and Cyclooxygenase by Dihydrothiazole Benzensulfonamides | 1-Jan-2018 | Meleddu, Rita; Distinto, Simona; Cottiglia, Filippo; Angius, Rossella; Gaspari, Marco; Taverna, Domenico; Melis, Claudia; Angeli, Andrea; Bianco, Giulia; Deplano, Serenella; Fois, Benedetta; Del Prete, Sonia; Capasso, Clemente; Alcaro, Stefano; Ortuso, Francesco; Yanez, Matilde; Supuran Claudiu, T.; Maccioni, Elias | ACS MEDICINAL CHEMISTRY LETTERS | - |
| N-Acylbenzenesulfonamide dihydro-1,3,4-oxadiazole hybrids: seeking selectivity toward carbonic anhydrase isoforms | 1-Jan-2017 | Bianco, Giulia; Meleddu, Rita; Distinto, Simona; Cottiglia, Filippo; Gaspari, Marco; Melis, Claudia; Corona, Angela; Angius, Rossella; Angeli, Andrea; Taverna, Domenico; Alcaro, Stefano; Leitans, Janis; Kazaks, Andris; Tars, Kaspars; Supuran, Claudiu T.; Maccioni, Elias | ACS MEDICINAL CHEMISTRY LETTERS | - |
| Multi-target activity of Hemidesmus indicus decoction against innovative HIV-1 drug targets and characterization of Lupeol mode of action | 1-Jan-2017 | Esposito, Francesca; Mandrone, Manuela; Del Vecchio, Claudia; Carli, Ilaria; Distinto, Simona; Corona, Angela; Lianza, Mariacaterina; Piano, Dario; Tacchini, Massimo; Maccioni, Elias; Cottiglia, Filippo; Saccon, Elisa; Poli, Ferruccio; Parolin, Cristina; Tramontano, Enzo | PATHOGENS AND DISEASE | - |
| Natural product-inspired esters and amides of ferulic and caffeic acid as dual inhibitors of HIV-1 reverse transcriptase | 1-Jan-2017 | Sonar, VIJAY PRAKASH; Corona, Angela; Distinto, Simona; Maccioni, Elias; Meleddu, Rita; Fois, Benedetta; Floris, Costantino; Malpure, Nilesh V.; Alcaro, Stefano; Tramontano, Enzo; Cottiglia, Filippo | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - |
| Design, synthesis and antiviral evaluation of novel heteroarylcarbothioamide derivatives as dual inhibitors of HIV-1 Reverse transcriptase-associated RNase H and RDDP functions | 1-Jan-2017 | Corona, Angela; Onnis, Valentina; Deplano, Alessandro; Bianco, Giulia; Demurtas, Monica; Distinto, Simona; Cheng, Yung Chi; Alcaro, Stefano; Esposito, Francesca; Tramontano, Enzo | PATHOGENS AND DISEASE | - |
| Isatin thiazoline hybrids as dual inhibitors of HIV-1 reverse transcriptase | 1-Jan-2017 | Meleddu, Rita; Distinto, Simona; Corona, Angela; Tramontano, Enzo; Bianco, Giulia; Melis, Claudia; Cottiglia, Filippo; Maccioni, Elias | JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | - |
| Through scaffold modification to 3,5-diaryl-4,5-dihydroisoxazoles: new potent and selective inhibitors of monoamine oxidase B | 1-Jan-2017 | Meleddu, Rita; Distinto, Simona; Cirilli, Roberto; Alcaro, Stefano; Yanez, Matilde; Sanna, MARIA LUISA; Corona, Angela; Melis, Claudia; Bianco, Giulia; Matyus, Peter; Cottiglia, Filippo; Maccioni, Elias | JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | - |
| Isatin: a privileged scaffold for the design of carbonic anhydrase inhibitors | 1-Jan-2017 | Melis, Claudia; Meleddu, Rita; Angeli, Andrea; Distinto, Simona; Bianco, Giulia; Capasso, Clemente; Cottiglia, Filippo; Angius, Rossella; Supuran, Claudiu T.; Maccioni, Elias | JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | - |
| Phenylpropenoids from Bupleurum fruticosum as Anti-Human Rhinovirus Species A Selective Capsid Binders | 1-Jan-2017 | Fois, Benedetta; Bianco, Giulia; Sonar, Vijay P.; Distinto, Simona; Maccioni, Elias; Meleddu, Rita; Melis, Claudia; Marras, Luisa; Pompei, Raffaello; Floris, Costantino; Caboni, Pierluigi; Cottiglia, Filippo | JOURNAL OF NATURAL PRODUCTS | - |
| Identification of G-quadruplex DNA/RNA binders: Structure-based virtual screening and biophysical characterization | 1-Jan-2017 | Rocca, R.; Moraca, F.; Costa, G.; Nadai, M.; Scalabrin, M.; Talarico, C.; Distinto, S.; Maccioni, E.; Ortuso, F.; Artese, A.; Alcaro, S.; Richter, S. N. | BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS | - |
| Exploring the thiazole scaffold for the identification of new agents for the treatment of fluconazole resistant Candida | 1-Jan-2016 | Meleddu, Rita; Distinto, Simona; Corona, Angela; Maccioni, Elias; Arridu, Antonella; Melis, Claudia; Bianco, Giulia; Matyus, Peter; Cottiglia, Filippo; Sanna, Adriana; DE LOGU, Alessandro | JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | - |
| Drug design, synthesis, in vitro and in silico evaluation of selective monoaminoxidase B inhibitors based on 3-acetyl-2-dichlorophenyl-5-aryl-2,3-dihydro-1,3,4-oxadiazole chemical scaffold | 1-Jan-2016 | Distinto, Simona; Meleddu, Rita; Yanez, Matilde; Cirilli, Roberto; Bianco, Giulia; Sanna, MARIA LUISA; Arridu, Antonella; Cossu, Pietro; Cottiglia, Filippo; Faggi, Cristina; Ortuso, Francesco; Alcaro, Stefano; Maccioni, Elias | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - |
| Hit Identification of a Novel Dual Binder for h-telo/c-myc G-Quadruplex by a Combination of Pharmacophore Structure-Based Virtual Screening and Docking Refinement | 1-Jan-2016 | Rocca, Roberta; Costa, Giosuè; Artese, Anna; Parrotta, Lucia; Ortuso, Francesco; Maccioni, Elias; Pinato, Odra; Greco, Maria Laura; Sissi, Claudia; Alcaro, Stefano; Distinto, Simona; Moraca, Federica | CHEMMEDCHEM | - |
| Ribonuclease H/DNA polymerase HIV-1 reverse transcriptase dual inhibitor: mechanistic studies on the allosteric mode of action of isatin-based compound RMNC6 | 1-Jan-2016 | Corona, Angela; Meleddu, Rita; Esposito, Francesca; Distinto, Simona; Bianco, Giulia; Masaoka, T; Maccioni, Elias; Menéndez Arias, L; Alcaro, S; Le Grice, Sfj; Tramontano, Enzo | PLOS ONE | - |
| Studies on Cycloheptathiophene-3-carboxamide Derivatives as Allosteric HIV-1 Ribonuclease H Inhibitors | 1-Jan-2016 | Corona, Angela; Desantis, Jenny; Massari, Serena; Distinto, Simona; Masaoka, Takashi; Sabatini, Stefano; Esposito, Francesca; Manfroni, Giuseppe; Maccioni, Elias; Cecchetti, Violetta; Pannecouque, Christophe; Le Grice, Stuart F. J; Tramontano, Enzo; Tabarrini, Oriana | CHEMMEDCHEM | - |
| Sennoside A, derived from the traditional chinese medicine plant Rheum L., is a new dual HIV-1 inhibitor effective on HIV-1 replication | 1-Jan-2016 | Esposito, Francesca; Carli, Ilaria; Del Vecchio, Claudia; Xu, Lijia; Corona, Angela; Grandi, Nicole; Piano, Dario; Maccioni, Elias; Distinto, Simona; Parolin, Cristina; Tramontano, Enzo | PHYTOMEDICINE | - |
| Methoxyflavones from Stachys glutinosa with binding affinity to opioid receptors: in silico, in vitro, and in vivo studies | 1-Jan-2015 | Ruiu, S; Anzani, N; Orrù, A; Floris, Costantino; Caboni, Pierluigi; Alcaro, S; Maccioni, Elias; Distinto, Simona; Cottiglia, Filippo | JOURNAL OF NATURAL PRODUCTS | - |
| New 4-[(3-cyclohexyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzene-1-sulfonamides, synthesis and inhibitory activity toward carbonic anhydrase I, II, IX, XII | 1-Jan-2015 | Meleddu, Rita; Maccioni, Elias; Distinto, Simona; Bianco, Giulia; Melis, Claudia; Alcaro, Stefano; Cottiglia, Filippo; Ceruso, Mariangela; Supuran, Claudiu T. | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
| (3Z)-3-(2-[4-(aryl)-1,3-thiazol-2-yl]hydrazin-1-ylidene)-2,3-dihydro- 1H -indol-2-one derivatives as dual inhibitors of HIV-1 reverse transcriptase | 1-Jan-2015 | Meleddu, Rita; Distinto, Simona; Corona, Angela; Bianco, Giulia; Cannas, Valeria; Esposito, Francesca; Artese, A; Alcaro, S; Matyus, P; Bogdan, D; Cottiglia, Filippo; Tramontano, Enzo; Maccioni, Elias | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - |
| Structure-based virtual screening of novel natural alkaloid derivatives as potential binders of h-telo and c-myc DNA G-quadruplex conformations | 1-Jan-2015 | Rocca, R.; Moraca, F.; Costa, G.; Alcaro, S.; Distinto, Simona; Maccioni, Elias; Ortuso, F.; Artese, A.; Parrotta, L. | MOLECULES | - |
| Site directed mutagenesis studies on HIV-1 reverse transcriptase (RT) enlighten the mechanism of action of a new Ribonuclease H/DNA polymerase RT dual inhibitor | 1-Jan-2014 | Esposito, Francesca; Corona, Angela; Meleddu, Rita; Distinto, Simona; Giulia, Bianco; Maccioni, Elias; Stuart JF Le Grice, ; Enzo, Tramontano | - | - |
| 2-methoxynaphthalen thiazole derivate : a new HIV-1 RT Ribonuclease H/DNA polymerase dual inhibitor active on viral replication | 1-Jan-2014 | Corona, Angela; Meleddu, R.; Esposito, E.; Distinto, S.; Bianco, G.; Maccioni, E.; Tramontano, E. . | - | - |
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