University of Cagliari
Marina Serra
Lead induces cell-autonomous proliferation and metabolic reprogramming of hepatocytes
2025-01-01 Serra, Marina; Smiriglia, Alfredo; Migliore, Cristina; Caddeo, Andrea; Lorito, Nicla; Tani, Gabriele; Zedda, Giorgia; Columbano, Amedeo; Perra, Andrea; Giordano, Silvia; Kowalik, Marta Anna; Morandi, Andrea
Targeting EIF4A1 is effective against human intrahepatic cholangiocarcinoma
2025-01-01 Mi, Wunan; Cigliano, Antonio; Galleri, Grazia; Gigante, Isabella; Steinmann, Sara Martina; Cibali, Ezgi; Serra, Marina; Pes, Giovanni Mario; Schloesser, Denise; Pizzuto, Elena; Siegmund, Heiko; Fischer, Claudia; Saborowski, Anna; Giannelli, Gianluigi; Evert, Matthias; Van Der Laan, Luc Johannes Wilhelmus; Verstegen, Monique Maria Andrea; Calvisi, Diego Francesco
Impact of the Human Leukocyte Antigen Complex on Idiopathic Pulmonary Fibrosis Development and Progression in the Sardinian Population
2025-01-01 Serra, Marina; Mocci, Stefano; Deidda, Silvia; Melis, Maurizio; Chessa, Luchino; Lai, Sara; Giuressi, Erika; Mereu, Caterina; Sanna, Celeste; Lorrai, Michela; Murgia, Michela; Cannas, Federica; Mascia, Alessia; Perra, Andrea; Littera, Roberto; Giglio, Sabrina
HSF1 is a prognostic determinant and therapeutic target in intrahepatic cholangiocarcinoma
2024-01-01 Cigliano, Antonio; Gigante, Isabella; Serra, Marina; Vidili, Gianpaolo; Simile, Maria M.; Steinmann, Sara; Urigo, Francesco; Cossu, Eleonora; Pes, Giovanni M.; Dore, Maria P.; Ribback, Silvia; Milia, Egle P.; Pizzuto, Elena; Mancarella, Serena; Che, Li; Pascale, Rosa M.; Giannelli, Gianluigi; Evert, Matthias; Chen, Xin; Calvisi, Diego F.
Metabolic reprogramming in Nrf2-driven proliferation of normal rat hepatocytes
2024-01-01 Kowalik, M. A.; Taguchi, K.; Serra, M.; Caddeo, A.; Puliga, E.; Bacci, M.; Koshiba, S.; Inoue, J.; Hishinuma, E.; Morandi, A.; Giordano, S.; Perra, A.; Yamamoto, M.; Columbano, A.
Potential use of TG68 - A novel thyromimetic - for the treatment of non-alcoholic fatty liver (NAFLD)-associated hepatocarcinogenesis
2023-01-01 Caddeo, A.; Serra, M.; Sedda, F.; Bacci, A.; Manera, C.; Rapposelli, S.; Columbano, A.; Perra, A.; Kowalik, M. A.
Sex difference in liver diseases: How preclinical models help to dissect the sex-related mechanisms sustaining NAFLD and hepatocellular carcinoma
2023-01-01 Smiriglia, A.; Lorito, N.; Serra, M.; Perra, A.; Morandi, A.; Kowalik, M. A.
Novel thyroid hormone receptor-beta agonist TG68 safely induces hepatic fat reduction in a non-alcoholic steatohepatitis rat model
2022-01-01 Caddeo, ANDREA MARCO; Kowalik, MARTA ANNA; Serra, Marina; Rapposelli, Simona; Columbano, Amedeo; Perra, Andrea
INHIBITORY EFFECT OF LDHA KNOCK-OUT ON METABOLIC REPROGRAMMING IN C-MYC/H-RAS DRIVEN HEPATOCELLULAR CARCINOMA
2022-01-01 Serra, Marina; di Matteo, Mario; Serneels, Jens; Pal, Rajesh; Trusso Cafarello, Sarah; Lanza, Martina; Sanchez-Martin, Carlos; Evert, Matthias; Castegna, Alessandra; Calvisi, Diego; Mazzone, Massimiliano; Columbano, Amedeo
Metabolic alterations of HCC are dependent upon different oncogene activation
2022-01-01 Serra, Marina; di Matteo, Mario; Serneels, Jens; Pal, Rajesh; Trusso Cafarello, Sarah; Lanza, Martina; Sanchez-Martina, Carlos; Evert, Matthias; Castegna, Alessandra; Calvisi, Diego; Mazzone, Massimiliano; Columbano, Amedeo
Novel thyroid hormone receptor-beta agonist TG68 safely induces hepatic fat reduction in a non-alcoholic steatohepatitis rat model
2022-01-01 Caddeo, ANDREA MARCO; Kowalik, MARTA ANNA; Serra, Marina; Rapposelli, Simona; Columbano, Amedeo; Perra, Andrea
Novel thyroid hormone receptor-beta agonist TG68 safely induces hepatic fat reduction in a non-alcoholic steatohepatitis rat model
2022-01-01 Caddeo, ANDREA MARCO; Kowalik, MARTA ANNA; Serra, Marina; Rapposelli, Simona; Columbano, Amedeo; Perra, Andrea
Oncogene-dependent HCC metabolic reprogramming
2022-01-01 Serra, Marina; Di Matteo, M.; Serneels, J.; Pal, R.; Trusso Cafarello, S.; Lanza, M.; Sanchez-Martin, C.; Evert, M.; Castegna, A.; Calvisi, D. F.; Mazzone, Massimiliano; Columbano, Amedeo
Deletion of Lactate Dehydrogenase-A Impairs Oncogene-Induced Mouse Hepatocellular Carcinoma Development
2022-01-01 Serra, Marina; Di Matteo, Mario; Serneels, Jens; Pal, Rajesh; Cafarello, Sarah Trusso; Lanza, Martina; Sanchez-Martin, Carlos; Evert, Matthias; Castegna, Alessandra; Calvisi, Diego Francesco; Mazzone, Massimiliano; Columbano, Amedeo
Nrf2 Mutation/Activation Is Dispensable for the Development of Chemically Induced Mouse HCC
2022-01-01 Mattu, Sandra; Zavattari, Patrizia; Kowalik, Marta Anna; Serra, Marina; Sulas, Pia; Pal, Rajesh; Puliga, Elisabetta; Sutti, Salvatore; Foglia, Beatrice; Parola, Maurizio; Albano, Emanuele; Giordano, Silvia; Perra, Andrea; Columbano, Amedeo
mRNA-miRNA networks identify metabolic pathways associated to the anti-tumorigenic effect of thyroid hormone on preneoplastic nodules and hepatocellular carcinoma
2022-01-01 Serra, Marina; Pal, Rajesh; Puliga, Elisabetta; Sulas, Pia; Cabras, Lavinia; Cusano, Roberto; Giordano, Silvia; Perra, Andrea; Columbano, Amedeo; Kowalik, Marta Anna
Diverse MicroRNAs-mRNA networks regulate the priming phase of mouse liver regeneration and of direct hyperplasia
2022-01-01 Pal, Rajesh; Kowalik, Marta Anna; Serra, Marina; Migliore, Cristina; Giordano, Silvia; Columbano, Amedeo; Perra, Andrea
METABOLIC REPROGRAMMING IN ONCOGENE-DRIVEN HEPATOCELLULAR CARCINOMA: EFFECT OF LDHA KNOCK-DOWN
2021-03-02
METABOLIC REPROGRAMMING IN A C-MYC/H-RAS TRANSGENIC MOUSE MODEL OF HEPATOCELLULAR CARCINOMA
2021-01-01 Serra, Marina; di Matteo, Mario; Mazzone, Massimiliano; Columbano, Amedeo
INIBITORY EFFECT OF LDHA KNOCK-DOWN ON METABOLIC REPROGRAMMING AND C-MYC/H-RAS DRIVEN HEPATOCELLULAR CARCINOMA
2021-01-01 Serra, Marina; di Matteo, Mario; Mazzone, Massimiliano; Columbano, Amedeo
Novel thyroid hormone receptor beta agonist TG68 safely induces hepatic fat loss reduction in a NASH mouse model
2021-01-01 Caddeo, ANDREA MARCO; Kowalik, MARTA ANNA; Serra, Marina; Runfola, Massimiliano; Bacci, Andrea; Rapposelli, Simona; Columbano, Amedeo; Perra, Andrea
Tg68, a novel thyroid hormone receptor‐β agonist for the treatment of NAFLD
2021-01-01 Caddeo, A.; Kowalik, M. A.; Serra, M.; Runfola, M.; Bacci, A.; Rapposelli, S.; Columbano, A.; Perra, A.
Glufosinate constrains synchronous and metachronous metastasis by promoting anti-tumor macrophages
2020-01-01 Menga, Alessio; Serra, Marina; Todisco, Simona; Riera-Domingo, Carla; Ammarah, Ummi; Ehling, Manuel; M Palmieri, Erika; Antonietta Di Noia, Maria; Gissi, Rosanna; Favia, Maria; L Pierri, Ciro; E Porporato, Paolo; Castegna, Alessandra; Mazzone, Massimiliano
Deregulation of cancer-stem-cell-associated miRNAs in tissues and sera of colorectal cancer patients
2020-01-01 Farace, C.; Pisano, A.; Grinan-Lison, C.; Solinas, G.; Jimenez, G.; Serra, M.; Carrillo, E.; Scognamillo, F.; Attene, F.; Montella, A.; Marchal, J. A.; Madeddu, R.
Understanding Metal Dynamics Between Cancer Cells and Macrophages: Competition or Synergism?
2020-01-01 Serra, M.; Columbano, A.; Ammarah, U.; Mazzone, M.; Menga, A.
Animal models: A useful tool to unveil metabolic changes in hepatocellular carcinoma
2020-01-01 Serra, M.; Columbano, A.; Perra, A.; Kowalik, M. A.
Combined CDK4/6 and pan-mTOR inhibition is synergistic against intrahepatic cholangiocarcinoma
2019-01-01 Song, X.; Liu, X.; Wang, H.; Wang, J.; Qiao, Y.; Cigliano, A.; Utpatel, K.; Ribback, S.; Pilo, M. G.; Serra, M.; Gordan, J. D.; Che, L.; Zhang, S.; Cossu, A.; Porcu, A.; Pascale, R. M.; Dombrowski, F.; Hu, H.; Calvisi, D. F.; Evert, M.; Chen, X.
THYROID HORMONE INHIBITS HEPATOCELLULAR CARCINOMA (HCC) DEVELOPMENT BY INTERFERING WITH THE METABOLIC PROFILE OF CANCER CELLS
2018-01-01 Serra, Marina; Cabras, Lavinia; Kowalik, MARTA ANNA; Perra, Andrea; Sanchez-Martin, Carlos; Rasola, Andrea; Columbano, Amedeo
Jagged 1 is a major Notch ligand along cholangiocarcinoma development in mice and humans
2016-01-01 Che, L.; Fan, B.; Pilo, M. G.; Xu, Z.; Liu, Y.; Cigliano, A.; Cossu, A.; Palmieri, G.; Pascale, R. M.; Porcu, A.; Vidili, G.; Serra, M.; Dombrowski, F.; Ribback, S.; Calvisi, D. F.; Chen, X.
| Title | Issue Date | Author(s) | Journal | Publisher |
|---|---|---|---|---|
| Lead induces cell-autonomous proliferation and metabolic reprogramming of hepatocytes | 1-Jan-2025 | Serra, Marina; Smiriglia, Alfredo; Migliore, Cristina; Caddeo, Andrea; Lorito, Nicla; Tani, Gabriele; Zedda, Giorgia; Columbano, Amedeo; Perra, Andrea; Giordano, Silvia; Kowalik, Marta Anna; Morandi, Andrea | CELL DEATH & DISEASE | - |
| Targeting EIF4A1 is effective against human intrahepatic cholangiocarcinoma | 1-Jan-2025 | Mi, Wunan; Cigliano, Antonio; Galleri, Grazia; Gigante, Isabella; Steinmann, Sara Martina; Cibali, Ezgi; Serra, Marina; Pes, Giovanni Mario; Schloesser, Denise; Pizzuto, Elena; Siegmund, Heiko; Fischer, Claudia; Saborowski, Anna; Giannelli, Gianluigi; Evert, Matthias; Van Der Laan, Luc Johannes Wilhelmus; Verstegen, Monique Maria Andrea; Calvisi, Diego Francesco | JHEP REPORTS | - |
| Impact of the Human Leukocyte Antigen Complex on Idiopathic Pulmonary Fibrosis Development and Progression in the Sardinian Population | 1-Jan-2025 | Serra, Marina; Mocci, Stefano; Deidda, Silvia; Melis, Maurizio; Chessa, Luchino; Lai, Sara; Giuressi, Erika; Mereu, Caterina; Sanna, Celeste; Lorrai, Michela; Murgia, Michela; Cannas, Federica; Mascia, Alessia; Perra, Andrea; Littera, Roberto; Giglio, Sabrina | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
| HSF1 is a prognostic determinant and therapeutic target in intrahepatic cholangiocarcinoma | 1-Jan-2024 | Cigliano, Antonio; Gigante, Isabella; Serra, Marina; Vidili, Gianpaolo; Simile, Maria M.; Steinmann, Sara; Urigo, Francesco; Cossu, Eleonora; Pes, Giovanni M.; Dore, Maria P.; Ribback, Silvia; Milia, Egle P.; Pizzuto, Elena; Mancarella, Serena; Che, Li; Pascale, Rosa M.; Giannelli, Gianluigi; Evert, Matthias; Chen, Xin; Calvisi, Diego F. | JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH | - |
| Metabolic reprogramming in Nrf2-driven proliferation of normal rat hepatocytes | 1-Jan-2024 | Kowalik, M. A.; Taguchi, K.; Serra, M.; Caddeo, A.; Puliga, E.; Bacci, M.; Koshiba, S.; Inoue, J.; Hishinuma, E.; Morandi, A.; Giordano, S.; Perra, A.; Yamamoto, M.; Columbano, A. | HEPATOLOGY | - |
| Potential use of TG68 - A novel thyromimetic - for the treatment of non-alcoholic fatty liver (NAFLD)-associated hepatocarcinogenesis | 1-Jan-2023 | Caddeo, A.; Serra, M.; Sedda, F.; Bacci, A.; Manera, C.; Rapposelli, S.; Columbano, A.; Perra, A.; Kowalik, M. A. | FRONTIERS IN ONCOLOGY | - |
| Sex difference in liver diseases: How preclinical models help to dissect the sex-related mechanisms sustaining NAFLD and hepatocellular carcinoma | 1-Jan-2023 | Smiriglia, A.; Lorito, N.; Serra, M.; Perra, A.; Morandi, A.; Kowalik, M. A. | ISCIENCE | - |
| Novel thyroid hormone receptor-beta agonist TG68 safely induces hepatic fat reduction in a non-alcoholic steatohepatitis rat model | 1-Jan-2022 | Caddeo, ANDREA MARCO; Kowalik, MARTA ANNA; Serra, Marina; Rapposelli, Simona; Columbano, Amedeo; Perra, Andrea | - | - |
| INHIBITORY EFFECT OF LDHA KNOCK-OUT ON METABOLIC REPROGRAMMING IN C-MYC/H-RAS DRIVEN HEPATOCELLULAR CARCINOMA | 1-Jan-2022 | Serra, Marina; di Matteo, Mario; Serneels, Jens; Pal, Rajesh; Trusso Cafarello, Sarah; Lanza, Martina; Sanchez-Martin, Carlos; Evert, Matthias; Castegna, Alessandra; Calvisi, Diego; Mazzone, Massimiliano; Columbano, Amedeo | - | - |
| Metabolic alterations of HCC are dependent upon different oncogene activation | 1-Jan-2022 | Serra, Marina; di Matteo, Mario; Serneels, Jens; Pal, Rajesh; Trusso Cafarello, Sarah; Lanza, Martina; Sanchez-Martina, Carlos; Evert, Matthias; Castegna, Alessandra; Calvisi, Diego; Mazzone, Massimiliano; Columbano, Amedeo | - | - |
| Novel thyroid hormone receptor-beta agonist TG68 safely induces hepatic fat reduction in a non-alcoholic steatohepatitis rat model | 1-Jan-2022 | Caddeo, ANDREA MARCO; Kowalik, MARTA ANNA; Serra, Marina; Rapposelli, Simona; Columbano, Amedeo; Perra, Andrea | - | - |
| Novel thyroid hormone receptor-beta agonist TG68 safely induces hepatic fat reduction in a non-alcoholic steatohepatitis rat model | 1-Jan-2022 | Caddeo, ANDREA MARCO; Kowalik, MARTA ANNA; Serra, Marina; Rapposelli, Simona; Columbano, Amedeo; Perra, Andrea | - | - |
| Oncogene-dependent HCC metabolic reprogramming | 1-Jan-2022 | Serra, Marina; Di Matteo, M.; Serneels, J.; Pal, R.; Trusso Cafarello, S.; Lanza, M.; Sanchez-Martin, C.; Evert, M.; Castegna, A.; Calvisi, D. F.; Mazzone, Massimiliano; Columbano, Amedeo | - | - |
| Deletion of Lactate Dehydrogenase-A Impairs Oncogene-Induced Mouse Hepatocellular Carcinoma Development | 1-Jan-2022 | Serra, Marina; Di Matteo, Mario; Serneels, Jens; Pal, Rajesh; Cafarello, Sarah Trusso; Lanza, Martina; Sanchez-Martin, Carlos; Evert, Matthias; Castegna, Alessandra; Calvisi, Diego Francesco; Mazzone, Massimiliano; Columbano, Amedeo | CMGH | - |
| Nrf2 Mutation/Activation Is Dispensable for the Development of Chemically Induced Mouse HCC | 1-Jan-2022 | Mattu, Sandra; Zavattari, Patrizia; Kowalik, Marta Anna; Serra, Marina; Sulas, Pia; Pal, Rajesh; Puliga, Elisabetta; Sutti, Salvatore; Foglia, Beatrice; Parola, Maurizio; Albano, Emanuele; Giordano, Silvia; Perra, Andrea; Columbano, Amedeo | CMGH | - |
| mRNA-miRNA networks identify metabolic pathways associated to the anti-tumorigenic effect of thyroid hormone on preneoplastic nodules and hepatocellular carcinoma | 1-Jan-2022 | Serra, Marina; Pal, Rajesh; Puliga, Elisabetta; Sulas, Pia; Cabras, Lavinia; Cusano, Roberto; Giordano, Silvia; Perra, Andrea; Columbano, Amedeo; Kowalik, Marta Anna | FRONTIERS IN ONCOLOGY | - |
| Diverse MicroRNAs-mRNA networks regulate the priming phase of mouse liver regeneration and of direct hyperplasia | 1-Jan-2022 | Pal, Rajesh; Kowalik, Marta Anna; Serra, Marina; Migliore, Cristina; Giordano, Silvia; Columbano, Amedeo; Perra, Andrea | CELL PROLIFERATION | - |
| METABOLIC REPROGRAMMING IN ONCOGENE-DRIVEN HEPATOCELLULAR CARCINOMA: EFFECT OF LDHA KNOCK-DOWN | 2-Mar-2021 | - | - | Università degli Studi di Cagliari |
| METABOLIC REPROGRAMMING IN A C-MYC/H-RAS TRANSGENIC MOUSE MODEL OF HEPATOCELLULAR CARCINOMA | 1-Jan-2021 | Serra, Marina; di Matteo, Mario; Mazzone, Massimiliano; Columbano, Amedeo | - | - |
| INIBITORY EFFECT OF LDHA KNOCK-DOWN ON METABOLIC REPROGRAMMING AND C-MYC/H-RAS DRIVEN HEPATOCELLULAR CARCINOMA | 1-Jan-2021 | Serra, Marina; di Matteo, Mario; Mazzone, Massimiliano; Columbano, Amedeo | - | - |
| Novel thyroid hormone receptor beta agonist TG68 safely induces hepatic fat loss reduction in a NASH mouse model | 1-Jan-2021 | Caddeo, ANDREA MARCO; Kowalik, MARTA ANNA; Serra, Marina; Runfola, Massimiliano; Bacci, Andrea; Rapposelli, Simona; Columbano, Amedeo; Perra, Andrea | - | - |
| Tg68, a novel thyroid hormone receptor‐β agonist for the treatment of NAFLD | 1-Jan-2021 | Caddeo, A.; Kowalik, M. A.; Serra, M.; Runfola, M.; Bacci, A.; Rapposelli, S.; Columbano, A.; Perra, A. | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
| Glufosinate constrains synchronous and metachronous metastasis by promoting anti-tumor macrophages | 1-Jan-2020 | Menga, Alessio; Serra, Marina; Todisco, Simona; Riera-Domingo, Carla; Ammarah, Ummi; Ehling, Manuel; M Palmieri, Erika; Antonietta Di Noia, Maria; Gissi, Rosanna; Favia, Maria; L Pierri, Ciro; E Porporato, Paolo; Castegna, Alessandra; Mazzone, Massimiliano | EMBO MOLECULAR MEDICINE | - |
| Deregulation of cancer-stem-cell-associated miRNAs in tissues and sera of colorectal cancer patients | 1-Jan-2020 | Farace, C.; Pisano, A.; Grinan-Lison, C.; Solinas, G.; Jimenez, G.; Serra, M.; Carrillo, E.; Scognamillo, F.; Attene, F.; Montella, A.; Marchal, J. A.; Madeddu, R. | ONCOTARGET | - |
| Understanding Metal Dynamics Between Cancer Cells and Macrophages: Competition or Synergism? | 1-Jan-2020 | Serra, M.; Columbano, A.; Ammarah, U.; Mazzone, M.; Menga, A. | FRONTIERS IN ONCOLOGY | - |
| Animal models: A useful tool to unveil metabolic changes in hepatocellular carcinoma | 1-Jan-2020 | Serra, M.; Columbano, A.; Perra, A.; Kowalik, M. A. | CANCERS | - |
| Combined CDK4/6 and pan-mTOR inhibition is synergistic against intrahepatic cholangiocarcinoma | 1-Jan-2019 | Song, X.; Liu, X.; Wang, H.; Wang, J.; Qiao, Y.; Cigliano, A.; Utpatel, K.; Ribback, S.; Pilo, M. G.; Serra, M.; Gordan, J. D.; Che, L.; Zhang, S.; Cossu, A.; Porcu, A.; Pascale, R. M.; Dombrowski, F.; Hu, H.; Calvisi, D. F.; Evert, M.; Chen, X. | CLINICAL CANCER RESEARCH | - |
| THYROID HORMONE INHIBITS HEPATOCELLULAR CARCINOMA (HCC) DEVELOPMENT BY INTERFERING WITH THE METABOLIC PROFILE OF CANCER CELLS | 1-Jan-2018 | Serra, Marina; Cabras, Lavinia; Kowalik, MARTA ANNA; Perra, Andrea; Sanchez-Martin, Carlos; Rasola, Andrea; Columbano, Amedeo | - | - |
| Jagged 1 is a major Notch ligand along cholangiocarcinoma development in mice and humans | 1-Jan-2016 | Che, L.; Fan, B.; Pilo, M. G.; Xu, Z.; Liu, Y.; Cigliano, A.; Cossu, A.; Palmieri, G.; Pascale, R. M.; Porcu, A.; Vidili, G.; Serra, M.; Dombrowski, F.; Ribback, S.; Calvisi, D. F.; Chen, X. | ONCOGENESIS | - |
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