University of Cagliari
Andrea Marco Caddeo
The role of OSM/OSMRβ axis in shaping the tumor microenvironment favoring MASLD-related HCC immune evasion
2026-01-01 Nurcis, J.; Foglia, B.; Rosso, C.; Provera, A.; Vecchio, C.; Maggiora, M.; Gambella, A.; Chianese, U.; Bocca, C.; Caviglia, G. P.; Benedetti, R.; Novo, E.; Bossi, F.; Doto, F.; Kowalik, M. A.; Caddeo, A.; Carucci, P.; Gaia, S.; Romagnoli, R.; Menconi, A.; Tusa, I.; Rovida, E.; Perra, A.; Bugianesi, E.; Altucci, L.; Albano, E.; Parola, M.; Sutti, S.; Cannito, S.
Deleterious effects of plastic component bisphenol a on mitochondrial function in human intestinal cells
2026-01-01 Perra, Giovanni; Caddeo, Andrea; Sedda, Francesca; Cao, Giacomo; Isola, Raffaella; Concas, Alessandro; Perra, Andrea; Lai, Nicola
TM6SF2 and PNPLA3: A potential dynamic duo?: Editorial on “TM6SF2 E167K variant decreases PNPLA3-mediated PUFA transfer to promote hepatic steatosis and injury in MASLD”
2025-01-01 Caddeo, A.; Mancina, R. M.
Galectin-3 inhibition ameliorates hepatic steatosis in a multilineage 3D spheroid model
2025-01-01 Sedda, Francesca; Caddeo, Andrea; Sasidharan, Kavitha; Perra, Giovanni; Pal, Rajesh; Lai, Nicola; Kowalik, Marta Anna; Perra, Andrea
Lead induces cell-autonomous proliferation and metabolic reprogramming of hepatocytes
2025-01-01 Serra, Marina; Smiriglia, Alfredo; Migliore, Cristina; Caddeo, Andrea; Lorito, Nicla; Tani, Gabriele; Zedda, Giorgia; Columbano, Amedeo; Perra, Andrea; Giordano, Silvia; Kowalik, Marta Anna; Morandi, Andrea
Precision medicine and nucleotide-based therapeutics to treat steatotic liver disease
2025-01-01 Caddeo, A.; Romeo, S.
Metabolic reprogramming in Nrf2-driven proliferation of normal rat hepatocytes
2024-01-01 Kowalik, M. A.; Taguchi, K.; Serra, M.; Caddeo, A.; Puliga, E.; Bacci, M.; Koshiba, S.; Inoue, J.; Hishinuma, E.; Morandi, A.; Giordano, S.; Perra, A.; Yamamoto, M.; Columbano, A.
IL32 downregulation lowers triglycerides and type I collagen in di-lineage human primary liver organoids
2024-01-01 Sasidharan, K; Caddeo, A; Jamialahmadi, O; Noto, Fr; Tomasi, M; Malvestiti, F; Ciociola, E; Tavaglione, F; Mancina, Rm; Cherubini, A; Bianco, C; Mirarchi, A; Männistö, V; Pihlajamäki, J; Kärjä, V; Grimaudo, S; Luukkonen, Pk; Qadri, S; Yki-Järvinen, H; Petta, S; Manfrini, S; Vespasiani-Gentilucci, U; Bruni, V; Valenti, L; Romeo, S.
Increased secretion of adipocyte-derived extracellular vesicles is associated with adipose tissue inflammation and the mobilization of excess lipid in human obesity
2024-01-01 Matilainen, Johanna; Berg, Viivi; Vaittinen, Maija; Impola, Ulla; Mustonen, Anne-Mari; Männistö, Ville; Malinen, Marjo; Luukkonen, Veera; Rosso, Natalia; Turunen, Tanja; Käkelä, Pirjo; Palmisano, Silvia; Arasu, Uma Thanigai; Sihvo, Sanna P; Aaltonen, Niina; Härkönen, Kai; Caddeo, Andrea; Kaminska, Dorota; Pajukanta, Päivi; Kaikkonen, Minna U; Tiribelli, Claudio; Käkelä, Reijo; Laitinen, Saara; Pihlajamäki, Jussi; Nieminen, Petteri; Rilla, Kirsi
3D culture models to study pathophysiology of steatotic liver disease
2024-01-01 Caddeo, A.; Maurotti, S.; Kovooru, L.; Romeo, S.
MBOAT7 in liver and extrahepatic diseases
2023-01-01 Caddeo, A.; Spagnuolo, R.; Maurotti, S.
Potential use of TG68 - A novel thyromimetic - for the treatment of non-alcoholic fatty liver (NAFLD)-associated hepatocarcinogenesis
2023-01-01 Caddeo, A.; Serra, M.; Sedda, F.; Bacci, A.; Manera, C.; Rapposelli, S.; Columbano, A.; Perra, A.; Kowalik, M. A.
Novel thyroid hormone receptor-beta agonist TG68 safely induces hepatic fat reduction in a non-alcoholic steatohepatitis rat model
2022-01-01 Caddeo, ANDREA MARCO; Kowalik, MARTA ANNA; Serra, Marina; Rapposelli, Simona; Columbano, Amedeo; Perra, Andrea
Novel thyroid hormone receptor-beta agonist TG68 safely induces hepatic fat reduction in a non-alcoholic steatohepatitis rat model
2022-01-01 Caddeo, ANDREA MARCO; Kowalik, MARTA ANNA; Serra, Marina; Rapposelli, Simona; Columbano, Amedeo; Perra, Andrea
Novel thyroid hormone receptor-beta agonist TG68 safely induces hepatic fat reduction in a non-alcoholic steatohepatitis rat model
2022-01-01 Caddeo, ANDREA MARCO; Kowalik, MARTA ANNA; Serra, Marina; Rapposelli, Simona; Columbano, Amedeo; Perra, Andrea
The role of MBOAT7 on fatty liver disease
2021-03-19
Tg68, a novel thyroid hormone receptor‐β agonist for the treatment of NAFLD
2021-01-01 Caddeo, A.; Kowalik, M. A.; Serra, M.; Runfola, M.; Bacci, A.; Rapposelli, S.; Columbano, A.; Perra, A.
Novel thyroid hormone receptor beta agonist TG68 safely induces hepatic fat loss reduction in a NASH mouse model
2021-01-01 Caddeo, ANDREA MARCO; Kowalik, MARTA ANNA; Serra, Marina; Runfola, Massimiliano; Bacci, Andrea; Rapposelli, Simona; Columbano, Amedeo; Perra, Andrea
LPIAT1/MBOAT7 contains a catalytic dyad transferring polyunsaturated fatty acids to lysophosphatidylinositol
2021-01-01 Caddeo, A.; Hedfalk, K.; Romeo, S.; Pingitore, P.
LPIAT1/MBOAT7 depletion increases triglyceride synthesis fueled by high phosphatidylinositol turnover
2021-01-01 Tanaka, Y.; Shimanaka, Y.; Caddeo, A.; Kubo, T.; Mao, Y.; Kubota, T.; Kubota, N.; Yamauchi, T.; Mancina, R. M.; Baselli, G.; Luukkonen, P.; Pihlajamaki, J.; Yki-Jarvinen, H.; Valenti, L.; Arai, H.; Romeo, S.; Kono, N.
Identification of novel loss of function variants in MBOAT7 resulting in intellectual disability
2020-01-01 Heidari, E.; Caddeo, A.; Zarabadi, K.; Masoudi, M.; Tavasoli, A. R.; Romeo, S.; Garshasbi, M.
The TM6SF2 E167K genetic variant induces lipid biosynthesis and reduces apolipoprotein B secretion in human hepatic 3D spheroids
2019-01-01 Prill, S.; Caddeo, A.; Baselli, G.; Jamialahmadi, O.; Dongiovanni, P.; Rametta, R.; Kanebratt, K. P.; Pujia, A.; Pingitore, P.; Mancina, R. M.; Linden, D.; Whatling, C.; Janefeldt, A.; Kozyra, M.; Ingelman-Sundberg, M.; Valenti, L.; Andersson, T. B.; Romeo, S.
MBOAT7 is anchored to endomembranes by six transmembrane domains
2019-01-01 Caddeo, A.; Jamialahmadi, O.; Solinas, G.; Pujia, A.; Mancina, R. M.; Pingitore, P.; Romeo, S.
Molecular analysis of three known and one novel LPL variants in patients with type I hyperlipoproteinemia
2018-01-01 Caddeo, A.; Mancina, R. M.; Pirazzi, C.; Russo, C.; Sasidharan, K.; Sandstedt, J.; Maurotti, S.; Montalcini, T.; Pujia, A.; Leren, T. P.; Romeo, S.; Pingitore, P.
Telomerase reverse transcriptase germline mutations and hepatocellular carcinoma in patients with nonalcoholic fatty liver disease
2017-01-01 Donati, B.; Pietrelli, A.; Pingitore, P.; Dongiovanni, P.; Caddeo, A.; Walker, L.; Baselli, G.; Pelusi, S.; Rosso, C.; Vanni, E.; Daly, A.; Mancina, R. M.; Grieco, A.; Miele, L.; Grimaudo, S.; Craxi, A.; Petta, S.; De Luca, L.; Maier, S.; Soardo, G.; Bugianesi, E.; Colli, F.; Romagnoli, R.; Anstee, Q. M.; Reeves, H. L.; Fracanzani, A. L.; Fargion, S.; Romeo, S.; Valenti, L.
PNPLA3 overexpression results in reduction of proteins predisposing to fibrosis
2016-01-01 Pingitore, P.; Dongiovanni, P.; Motta, B. M.; Meroni, M.; Lepore, S. M.; Mancina, R. M.; Pelusi, S.; Russo, C.; Caddeo, A.; Rossi, G.; Montalcini, T.; Pujia, A.; Wiklund, O.; Valenti, L.; Romeo, S.
| Title | Issue Date | Author(s) | Journal | Publisher |
|---|---|---|---|---|
| The role of OSM/OSMRβ axis in shaping the tumor microenvironment favoring MASLD-related HCC immune evasion | 1-Jan-2026 | Nurcis, J.; Foglia, B.; Rosso, C.; Provera, A.; Vecchio, C.; Maggiora, M.; Gambella, A.; Chianese, U.; Bocca, C.; Caviglia, G. P.; Benedetti, R.; Novo, E.; Bossi, F.; Doto, F.; Kowalik, M. A.; Caddeo, A.; Carucci, P.; Gaia, S.; Romagnoli, R.; Menconi, A.; Tusa, I.; Rovida, E.; Perra, A.; Bugianesi, E.; Altucci, L.; Albano, E.; Parola, M.; Sutti, S.; Cannito, S. | HEPATOLOGY | - |
| Deleterious effects of plastic component bisphenol a on mitochondrial function in human intestinal cells | 1-Jan-2026 | Perra, Giovanni; Caddeo, Andrea; Sedda, Francesca; Cao, Giacomo; Isola, Raffaella; Concas, Alessandro; Perra, Andrea; Lai, Nicola | TOXICOLOGY | - |
| TM6SF2 and PNPLA3: A potential dynamic duo?: Editorial on “TM6SF2 E167K variant decreases PNPLA3-mediated PUFA transfer to promote hepatic steatosis and injury in MASLD” | 1-Jan-2025 | Caddeo, A.; Mancina, R. M. | CLINICAL AND MOLECULAR HEPATOLOGY | - |
| Galectin-3 inhibition ameliorates hepatic steatosis in a multilineage 3D spheroid model | 1-Jan-2025 | Sedda, Francesca; Caddeo, Andrea; Sasidharan, Kavitha; Perra, Giovanni; Pal, Rajesh; Lai, Nicola; Kowalik, Marta Anna; Perra, Andrea | PLOS ONE | - |
| Lead induces cell-autonomous proliferation and metabolic reprogramming of hepatocytes | 1-Jan-2025 | Serra, Marina; Smiriglia, Alfredo; Migliore, Cristina; Caddeo, Andrea; Lorito, Nicla; Tani, Gabriele; Zedda, Giorgia; Columbano, Amedeo; Perra, Andrea; Giordano, Silvia; Kowalik, Marta Anna; Morandi, Andrea | CELL DEATH & DISEASE | - |
| Precision medicine and nucleotide-based therapeutics to treat steatotic liver disease | 1-Jan-2025 | Caddeo, A.; Romeo, S. | CLINICAL AND MOLECULAR HEPATOLOGY | - |
| Metabolic reprogramming in Nrf2-driven proliferation of normal rat hepatocytes | 1-Jan-2024 | Kowalik, M. A.; Taguchi, K.; Serra, M.; Caddeo, A.; Puliga, E.; Bacci, M.; Koshiba, S.; Inoue, J.; Hishinuma, E.; Morandi, A.; Giordano, S.; Perra, A.; Yamamoto, M.; Columbano, A. | HEPATOLOGY | - |
| IL32 downregulation lowers triglycerides and type I collagen in di-lineage human primary liver organoids | 1-Jan-2024 | Sasidharan, K; Caddeo, A; Jamialahmadi, O; Noto, Fr; Tomasi, M; Malvestiti, F; Ciociola, E; Tavaglione, F; Mancina, Rm; Cherubini, A; Bianco, C; Mirarchi, A; Männistö, V; Pihlajamäki, J; Kärjä, V; Grimaudo, S; Luukkonen, Pk; Qadri, S; Yki-Järvinen, H; Petta, S; Manfrini, S; Vespasiani-Gentilucci, U; Bruni, V; Valenti, L; Romeo, S. | CELL REPORTS MEDICINE | - |
| Increased secretion of adipocyte-derived extracellular vesicles is associated with adipose tissue inflammation and the mobilization of excess lipid in human obesity | 1-Jan-2024 | Matilainen, Johanna; Berg, Viivi; Vaittinen, Maija; Impola, Ulla; Mustonen, Anne-Mari; Männistö, Ville; Malinen, Marjo; Luukkonen, Veera; Rosso, Natalia; Turunen, Tanja; Käkelä, Pirjo; Palmisano, Silvia; Arasu, Uma Thanigai; Sihvo, Sanna P; Aaltonen, Niina; Härkönen, Kai; Caddeo, Andrea; Kaminska, Dorota; Pajukanta, Päivi; Kaikkonen, Minna U; Tiribelli, Claudio; Käkelä, Reijo; Laitinen, Saara; Pihlajamäki, Jussi; Nieminen, Petteri; Rilla, Kirsi | JOURNAL OF TRANSLATIONAL MEDICINE | - |
| 3D culture models to study pathophysiology of steatotic liver disease | 1-Jan-2024 | Caddeo, A.; Maurotti, S.; Kovooru, L.; Romeo, S. | ATHEROSCLEROSIS | - |
| MBOAT7 in liver and extrahepatic diseases | 1-Jan-2023 | Caddeo, A.; Spagnuolo, R.; Maurotti, S. | LIVER INTERNATIONAL | - |
| Potential use of TG68 - A novel thyromimetic - for the treatment of non-alcoholic fatty liver (NAFLD)-associated hepatocarcinogenesis | 1-Jan-2023 | Caddeo, A.; Serra, M.; Sedda, F.; Bacci, A.; Manera, C.; Rapposelli, S.; Columbano, A.; Perra, A.; Kowalik, M. A. | FRONTIERS IN ONCOLOGY | - |
| Novel thyroid hormone receptor-beta agonist TG68 safely induces hepatic fat reduction in a non-alcoholic steatohepatitis rat model | 1-Jan-2022 | Caddeo, ANDREA MARCO; Kowalik, MARTA ANNA; Serra, Marina; Rapposelli, Simona; Columbano, Amedeo; Perra, Andrea | - | - |
| Novel thyroid hormone receptor-beta agonist TG68 safely induces hepatic fat reduction in a non-alcoholic steatohepatitis rat model | 1-Jan-2022 | Caddeo, ANDREA MARCO; Kowalik, MARTA ANNA; Serra, Marina; Rapposelli, Simona; Columbano, Amedeo; Perra, Andrea | - | - |
| Novel thyroid hormone receptor-beta agonist TG68 safely induces hepatic fat reduction in a non-alcoholic steatohepatitis rat model | 1-Jan-2022 | Caddeo, ANDREA MARCO; Kowalik, MARTA ANNA; Serra, Marina; Rapposelli, Simona; Columbano, Amedeo; Perra, Andrea | - | - |
| The role of MBOAT7 on fatty liver disease | 19-Mar-2021 | - | - | Università degli Studi di Cagliari |
| Tg68, a novel thyroid hormone receptor‐β agonist for the treatment of NAFLD | 1-Jan-2021 | Caddeo, A.; Kowalik, M. A.; Serra, M.; Runfola, M.; Bacci, A.; Rapposelli, S.; Columbano, A.; Perra, A. | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
| Novel thyroid hormone receptor beta agonist TG68 safely induces hepatic fat loss reduction in a NASH mouse model | 1-Jan-2021 | Caddeo, ANDREA MARCO; Kowalik, MARTA ANNA; Serra, Marina; Runfola, Massimiliano; Bacci, Andrea; Rapposelli, Simona; Columbano, Amedeo; Perra, Andrea | - | - |
| LPIAT1/MBOAT7 contains a catalytic dyad transferring polyunsaturated fatty acids to lysophosphatidylinositol | 1-Jan-2021 | Caddeo, A.; Hedfalk, K.; Romeo, S.; Pingitore, P. | BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | - |
| LPIAT1/MBOAT7 depletion increases triglyceride synthesis fueled by high phosphatidylinositol turnover | 1-Jan-2021 | Tanaka, Y.; Shimanaka, Y.; Caddeo, A.; Kubo, T.; Mao, Y.; Kubota, T.; Kubota, N.; Yamauchi, T.; Mancina, R. M.; Baselli, G.; Luukkonen, P.; Pihlajamaki, J.; Yki-Jarvinen, H.; Valenti, L.; Arai, H.; Romeo, S.; Kono, N. | GUT | - |
| Identification of novel loss of function variants in MBOAT7 resulting in intellectual disability | 1-Jan-2020 | Heidari, E.; Caddeo, A.; Zarabadi, K.; Masoudi, M.; Tavasoli, A. R.; Romeo, S.; Garshasbi, M. | GENOMICS | - |
| The TM6SF2 E167K genetic variant induces lipid biosynthesis and reduces apolipoprotein B secretion in human hepatic 3D spheroids | 1-Jan-2019 | Prill, S.; Caddeo, A.; Baselli, G.; Jamialahmadi, O.; Dongiovanni, P.; Rametta, R.; Kanebratt, K. P.; Pujia, A.; Pingitore, P.; Mancina, R. M.; Linden, D.; Whatling, C.; Janefeldt, A.; Kozyra, M.; Ingelman-Sundberg, M.; Valenti, L.; Andersson, T. B.; Romeo, S. | SCIENTIFIC REPORTS | - |
| MBOAT7 is anchored to endomembranes by six transmembrane domains | 1-Jan-2019 | Caddeo, A.; Jamialahmadi, O.; Solinas, G.; Pujia, A.; Mancina, R. M.; Pingitore, P.; Romeo, S. | JOURNAL OF STRUCTURAL BIOLOGY | - |
| Molecular analysis of three known and one novel LPL variants in patients with type I hyperlipoproteinemia | 1-Jan-2018 | Caddeo, A.; Mancina, R. M.; Pirazzi, C.; Russo, C.; Sasidharan, K.; Sandstedt, J.; Maurotti, S.; Montalcini, T.; Pujia, A.; Leren, T. P.; Romeo, S.; Pingitore, P. | NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES | - |
| Telomerase reverse transcriptase germline mutations and hepatocellular carcinoma in patients with nonalcoholic fatty liver disease | 1-Jan-2017 | Donati, B.; Pietrelli, A.; Pingitore, P.; Dongiovanni, P.; Caddeo, A.; Walker, L.; Baselli, G.; Pelusi, S.; Rosso, C.; Vanni, E.; Daly, A.; Mancina, R. M.; Grieco, A.; Miele, L.; Grimaudo, S.; Craxi, A.; Petta, S.; De Luca, L.; Maier, S.; Soardo, G.; Bugianesi, E.; Colli, F.; Romagnoli, R.; Anstee, Q. M.; Reeves, H. L.; Fracanzani, A. L.; Fargion, S.; Romeo, S.; Valenti, L. | CANCER MEDICINE | - |
| PNPLA3 overexpression results in reduction of proteins predisposing to fibrosis | 1-Jan-2016 | Pingitore, P.; Dongiovanni, P.; Motta, B. M.; Meroni, M.; Lepore, S. M.; Mancina, R. M.; Pelusi, S.; Russo, C.; Caddeo, A.; Rossi, G.; Montalcini, T.; Pujia, A.; Wiklund, O.; Valenti, L.; Romeo, S. | HUMAN MOLECULAR GENETICS | - |
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