Antimicrobial activity of 10-(diphenylmethylene)-4-azatricyclo[5.2.1.0 2,6]dec-8-ene-3,5-dione derivatives

STEFANSKA J;BIELENICA A;STRUGA M;TYSKI S;KOSSAKOWSKI J;LA COLLA P;TAMBURINI, ELENA;LODDO, ROBERTA

2010-01-01

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Abstract

Antibacterial and antifungal activity of 10-(diphenylmethylene)-4- azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione derivatives were examined by the disk diffusion method (growth inhibition zone diameter in agar medium). The minimal inhibitory concentrations (MICs) for the most active agents were determined. Title compounds were also evaluated in vitro against HIV-1 virus and their cytotoxicity was determined. Aminoalkanol derivatives exhibited activity against the majority of microorganisms studied.