Sandwich-type (η6-p-cymene)Ru(η5-thiophene) complexes: synthesis, spectroscopic and electrochemical characterization, and antimicrobial activity

Maria I Pilo

;Antonio Zucca;Giuseppe Vacca;G. Sanna;Nadia Spano;Germano Orru;Alessandra Scano

2025-01-01

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Abstract

uthenium-arene derivatives have displayed in recent years interesting in vitro and in vivo biological activity. The features of sulphur-containing molecules as active components of drugs are known as well. Therefore, combining a Ru(arene)-core with a η-coordinated thiophene ligand can allow to tune the structure and the chemical and biological behavior of the resulting species. In this context, the synthesis of two hetero-sandwich ruthenium(II) complexes with a [(η6-arene)Ru(η5-R-thiophene)]2+ general formula has been performed, with the aim to investigate the effect of an alkyl substituent of the heterocycle ring on the spectroscopic and redox behavior. p-Cymene has been selected as arene ligand, whereas 3-methylthiophene and 3-octylthiophene acted as η5-ligand to complete the sandwich structure. The proposed structure was confirmed by a full 1H and 13C NMR characterization. UV-Vis spectra and voltammetric responses show that the length of the alkyl chain does not affect significantly the spectroscopic and redox behavior of these ruthenium complexes. On the other side, their activity towards Gram-positive and Gram-negative bacteria seems to depend on steric effects ascribed to the alkyl chain. The evaluated compounds are promising as bases for developing new antimicrobials, for example, to treat skin or oral infections.