Electrical Conductivity as an Informative Factor of the Properties of Liposomal Systems with Naproxen Sodium for Transdermal Application

Musial W.;Caddeo C.

Second

;Jankowska-Konsur A.;Passiu G.;Urbaniak T.;Twarda M.;Zalewski A.

2024-01-01

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Abstract

Liposomal preparations play an important role as formulations for transdermal drug delivery; however, the electrical conductivity of these systems is sparingly evaluated. The aim of the study was to outline the range of the values of electrical conductivity values that may be recorded in the future pharmaceutical systems in the context of their viscosity. The electrical conductivity, measured by a conductivity probe of k = 1.0 cm−1, and the dynamic viscosity of liposomal and non-liposomal systems with naproxen sodium, embedded into a methylcellulose hydrophilic gel (0.25%), were compared with data from preparations without naproxen sodium in a range reflecting the naproxen sodium concentrations 0.1·10−2–9.5·10−2 mol/L. The specific conductivity covered a 1.5 μS·cm−1–5616.0 μS·cm−1 range, whereas the viscosity ranged from 0.9 to 9.4 mPa·s. The naproxen sodium highly influenced the electrical conductivity, whereas the dynamic viscosity was a moderate factor. The observed phenomena may be ascribed to the high mobility of sodium ions recruited from naproxen sodium and the relatively low concentrations of applied methylcellulose. The assembly of lecithin in liposomes may have lowered the specific conductivity of the systems with naproxen sodium. These measurements will be further developed for implementation as simple assays of the concentrations of active pharmaceutical ingredient in release experiments of preparations proposed for dermatological applications.