Perspectives on Precision Psychiatry Using Antipsychotics in the Management of Bipolar Disorder

Fornaro M.

First

;Miola A.;De Berardis D.;Squassina A.

Writing - Review & Editing

;Manchia M.

Writing - Review & Editing

;Solmi M.

2025-01-01

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Abstract

Background/Objectives: Precision medicine is not just hype. Instead, it represents a high bar for developing more effective, safer, and better-tolerated therapies in medicine, without exception in psychiatry, including bipolar disorder (BD). A burgeoning body of narrative reviews and perspective papers has already appraised the boundaries of precision medicine in BD. Methods: This brief perspective follows a narrative, critical approach focusing explicitly on the antipsychotic management of BD using precision approaches. Results: While most controversies align with those previously appraised in BD’s overall precision medicine approach, specific insights are provided herein. Conclusions: Beyond other implications and the strengthened call for valid diagnostic coding systems, the implementation of shared decision-making tools and pharmacogenomics studies focusing on persons with BD are particularly warranted.