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COVID-19 infection is a significant risk factor for death in patients presenting with acute cholecystitis: a secondary analysis of the ChoCO-W cohort study

Podda, Mauro;Medas, Fabio;Canu, Gian Luigi;Cappellacci, Federico;Pisanu, Adolfo;Nardello, Oreste;
2025-01-01

Abstract

Background: During the coronavirus disease (COVID-19) pandemic, there has been a surge in cases of acute cholecystitis. The ChoCO-W global prospective study reported a higher incidence of gangrenous cholecystitis and adverse outcomes in COVID-19 patients. Through this secondary analysis of the ChoCO-W study data, we aim to identify significant risk factors for mortality in patients with acute cholecystitis during the COVID-19 pandemic, emphasizing the role of COVID-19 infection in patient outcomes and treatment efficacy.” Methods: The ChoCO-W global prospective study reported data from 2546 patients collected at 218 centers from 42 countries admitted with acute cholecystitis during the COVID-19 pandemic, from October 1, 2020, to October 31, 2021. Sixty-four of them died. Nonparametric statistical univariate analysis was performed to compare patients who died and patients who survived. Significant factors were then entered into a logistic regression model to define factors predicting mortality. Results: The significant independent factors that predicted death in the logistic regression model with were COVID-19 infection (p < 0.001), postoperative complications (p < 0.001), and type (open/laparoscopic) of surgical intervention (p = 0.003). The odds of death increased 5 times with the COVID-19 infection, 6 times in the presence of complications, and it was reduced by 86% with adequate source control. Survivors predominantly underwent urgent laparoscopic cholecystectomy (52.3% vs. 23.4%). Conclusions: COVID-19 was an independent risk factor for death in patients with acute cholecystitis. Early laparoscopic cholecystectomy has emerged as the cornerstone of treatment for hemodynamically stable patients.
2025
Inglese
WORLD JOURNAL OF EMERGENCY SURGERY
20
1
16
11
WOS:001432625400001
2-s2.0-85219173170
40001181
https://wjes.biomedcentral.com/articles/10.1186/s13017-025-00591-w
Esperti anonimi
scientifica
Acute cholecystitis
Covid-19
Emergency
Laparoscopic cholecystectomy
Management
Mortality
Sars-CoV-2
Goal 3: Good health and well-being
sì
De Simone, Belinda; Abu-Zidan, Fikri M.; Kasongo, Lucienne; Moore, Ernest E.; Podda, Mauro; Sartelli, Massimo; Isik, Arda; Bala, Miklosh; Coimbra, Rau ...espandi
1.1 Articolo in rivista
info:eu-repo/semantics/article
1 Contributo su Rivista::1.1 Articolo in rivista
262
382
open
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