The prognostic value of health-related quality of life for early molecular response in patients with chronic myeloid leukemia: analysis of the GIMEMA-SUSTRENIM trial

Efficace, Fabio;Cannella, Laura;Capodanno, Isabella;Sancetta, Rosaria;Porcu, Veronica;Lunghi, Monia;Biagi, Annalisa;Castagnetti, Fausto;Caocci, Giovanni;Baldi, Thomas;Marasca, Roberto;Bonifacio, Massimiliano;Gozzini, Antonella;Martino, Bruno;Sora, Federica;Westerweel, Peter E;Fazi, Paola;Vignetti, Marco;Pane, Fabrizio;Breccia, Massimo

2025-01-01

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Abstract

We aimed to explore the prognostic value of patient-reported health-related quality of life (HRQoL) data for the achievement of early molecular response (EMR) at 3 months in patients with chronic phase chronic myeloid leukemia (CP-CML). We analyzed HRQoL baseline data of 436 newly diagnosed patients with CML patients enrolled in the GIMEMA Sustrenim trial. HRQoL was assessed by the EORTC QLQ-30 and the QLQ-CML24 questionnaires. In the multivariate analysis, the following factors were found to be independently associated with achievement of EMR: Sokal risk (low vs intermediate risk p=0.046 and low vs high risk p<0.001), nilotinib treatment (p<0.001) and higher patient-reported role functioning (EORTC QLQ-C30) (p<0.001). Current findings suggest the importance of assessing HRQoL at diagnostic workup of patients with CML as it may provide valuable prognostic information.