Ghiani Emilio
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Emilio Ghiani

Xanthine Oxidase-Dependent Activation of NLPR3 Inflammasome in Epithelial Cells Sustains Inflammation in Inflammatory Bowel Disease

Di Petrillo, Amalia
First
Conceptualization
;Fais, Antonella;Raho, Nicola;Era, Benedetta;Cannea, Faustina Barbara;Padiglia, Alessandra;Grecu, Eleonora;Murtas, Daniela;Maxia, Cristina;Sogos, Valeria;Porcedda, Clara;Caboni, Pierluigi;Demurtas, Mauro;Favale, Agnese
Writing - Review & Editing
;Onali, Sara
Penultimate
Writing - Review & Editing
;Fantini, Massimo Claudio
Last
Conceptualization
2025-01-01

Abstract

Xanthine Oxidase is overexpressed in inflamed mucosa of IBD patients, promoting NLRP3 inflammasome activation and proinflammatory cytokine release. Ex vivo inhibition of Xanthine Oxidase by febuxostat or allopurinol suppressed inflammation representing a potential therapeutic approach for inflammatory bowel disease.
2025
Inglese
INFLAMMATORY BOWEL DISEASES
31
12
3398
3406
9
WOS:001597656100001
2-s2.0-105024493238
41124322
Esperti anonimi
scientifica
inflammasome
inflammatory bowel disease
xanthine oxidase
no
Di Petrillo, Amalia; Fais, Antonella; Raho, Nicola; Era, Benedetta; Cannea, Faustina Barbara; Padiglia, Alessandra; Grecu, Eleonora; Murtas, Daniela; ...espandi
1.1 Articolo in rivista
info:eu-repo/semantics/article
1 Contributo su Rivista::1.1 Articolo in rivista
262
16
open
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15. Dipetrillo2025.pdf

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Type: versione editoriale
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