The process of angiogenesis in neurodegeneration-pathomechanisms and new therapeutic interventions

Kieliszek-Ryba, Paulina;Jakimiuk, Anna;Kurek, Joanna;Simola, Nicola

Writing - Review & Editing

;Caria, Francesca;Piątkowska-Chmiel, Iwona;Herbet, Mariola

2026-01-01

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Abstract

Objective: Neurodegenerative diseases are a leading cause of disability worldwide, and recent evidence highlights the role of angiogenesis in their pathophysiology. This review aimed to explore molecular and metabolic links between neurodegeneration and angiogenesis, and to assess the potential of antiangiogenic drugs as therapeutic agents. Methods: A targeted literature search of experimental and clinical studies was performed, focusing on angiogenesis-related mechanisms in neurodegeneration and the effects of antiangiogenic compounds on neuronal and vascular function. Results: Antiangiogenic agents have been shown to promote synaptic plasticity, enhance neurotransmission, and exert anti-inflammatory effects. They also modulate vascular remodeling, which supports optimal cerebral blood flow and nutrient delivery to neurons. These actions may counteract key pathological processes in neurodegenerative diseases and help preserve cognitive and motor function. Conclusions: Modulation of angiogenesis represents a promising therapeutic approach in neurodegenerative disorders. Antiangiogenic drugs may address both vascular and neuronal dysfunction, offering a potential avenue for disease-modifying treatments. Further preclinical and clinical research is needed to validate their safety, efficacy, and long-term benefits.