Metabolomics and pediatric cardiology

PINTUS, Roberta;Dessi', Angelica;BOSCO, Alice;MUSSAP, Michele;BASSAREO, Pier P.;FANOS, Vassilios

2025-01-01

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Abstract

: Nowadays, pediatric cardiology is still a very complex topic. Children are not small adults and very little is known about how heart diseases can affect their metabolic profile both in the acute phase and in the long term. In this context, metabolomics analysis could provide multiple information in the field of pediatric cardiology. For instance, it could be used to predict the occurrence of fetal cardiac abnormalities or predict the outcomes of complex open-heart surgeries for each patient to improve the survival rate and provide better treatment. In this review, the authors describe all the metabolomics applied to pediatric cardiology studies from 2013 to 2024. We noted that the most discussed topics are congenital heart diseases, probably due to the complexity of these patients. Nevertheless, even if the number of studies is limited, they highlight the multiple possibilities provided by metabolomics for the management of neonates and children with heart diseases.