Obesity, Inflammation and Neurogical alteration

SPINAS, ENRICO;A. SAGGINI;SK KRITAS;G. CERULLI;A. CARAFFA;P. ANTINOLFI;A. PANTALONE;A. FRYDAS;M. TEI;A. SPEZIALI;R. SAGGINI;P. CONTI

2014-01-01

---

Abstract

Inflammation, neurodegeneration, imbalance of neurotransmitter systems, oxidative stress and depression are all risk factors for obesity. There is evidence regarding the cross-talk between adipose tissue and the immune system and obese patients may show an alteration of immune functions with major depression, including immune suppression with reduced T-cell and macrophage activity. Obesity is mediated by inflammatory cells such as lymphocytes, macrophages and mast cells which release pro-inflammatory cytokines and chemokines. Obesity-induced leukocyte infiltrations in adipose tissue cause cytokine/chemokine release and inflammation. Here, we report the relationship between obesity, neurological alterations and inflammation.