Solvent-free, continuous synthesis of hydrazone-based active pharmaceutical ingredients by twin-screw extrusion

Crawford D. E.

Writing – Original Draft Preparation

;Porcheddu A.;McCalmont A. S.

Membro del Collaboration Group

;Delogu F.

Membro del Collaboration Group

;James S. L.

Membro del Collaboration Group

;Colacino E.

Writing – Review & Editing

2020-01-01

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Abstract

Twin-screw extrusion (TSE) was used to synthesize hydantoin-based active pharmaceutical ingredients (APIs) such as nitrofurantoin and dantrolene, employing minimal or no solvent. Postsynthetic workup was not required. This work demonstrates that solvent-free synthesis can be conducted in a continuous manner for pharmaceutical products.