Università degli Studi di Cagliari
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N-Formylsaccharin: A Sweet(able) Formylating Agent in Mechanochemistry
Basoccu, Francesco;Fattuoni, Claudia
;Porcheddu, Andrea
2022-01-01
Abstract
The acylation of amines has always attracted a deep interest as a synthetic route due to its high versatility in organic chemistry and biochemical processes. The purpose of this article is to present a mechanochemical acylation procedure based on the use of acyl-saccharin derivatives, namely N-formylsaccharin, N-acetylsaccharin, and N-propionylsaccharin. This protocol furnishes a valuable solvent-free alternative to the existing processes and aims to be highly beneficial in multi-step procedures due to its rapid and user-friendly workup.
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