Application of Bertagnini's Salts in a Mechanochemical Approach Toward Aza-Heterocycles and Reductive Aminations via Imine Formation

Behera S.;Kanti Bera S.;Basoccu F.;Cuccu F.

Membro del Collaboration Group

;Caboni P.

Membro del Collaboration Group

;De Luca L.;Porcheddu A.

Conceptualization

2024-01-01

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Abstract

Our research has demonstrated that mechanochemical activation is more effective with solid reagents. We have showcased the practicality of Bertagnini's salts, also called aldehyde-bisulfite adducts, which are crystalline, simplifying preparation and storage. These salts are stable substitutes for liquid aldehydes and ketones that have been employed in reductive amination, synthesizing aza-heterocycles and hydrazones within mechanochemistry. The technique‘s effectiveness broadens the substrate scopes, simplifies purification, reduces reaction times, and yields the desired products ranging from 38–91%. Additionally, the thermal stability of the bisulfite adducts has been confirmed through TGA (Thermogravimetric analysis) analysis.