Suboptimal disease control and contributing factors in Italian IBD patients: The IBD-PODCAST Study

Calabrese, Emma;Onali, Sara;Variola, Angela;Ribaldone, Davide Giuseppe;Savarino, Edoardo Vincenzo;Viola, Anna;Saibeni, Simone;Conforti, Francesco Simone;Testa, Anna;Latella, Giovanni;Orlando, Ambrogio;Principi, Mariabeatrice;Privitera, Antonino Carlo;Guerra, Maria;Ceccarelli, Linda;Mocci, Giammarco;Boy, Davide;Piccarozzi, Maria Adelaide;Gualberti, Giuliana;Marando, Francesca;Gemignani, Lorenzo;D'Amico, Ferdinando

2025-01-01

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Abstract

Background and aim: Suboptimal disease control (SDC) and its contributing factors in IBD according to STRIDE-II criteria is unclear. IBD-PODCAST was a non-interventional, international, multicenter real-world study to assess this. Methods: Data from the Italian IBD cohort (N=220) are presented here. Participants aged ≥19 with confirmed IBD diagnosis of ≥1 year were consecutively enrolled. A retrospective chart review and cross-sectional assessment by physicians and patients within the past 12 months were performed. SDC or optimal disease control was assessed using adapted STRIDE-II criteria. Results: At the index date, 53.4 % of 116 CD patients and 49.0 % of 104 UC patients had SDC, mainly attributed to a Short Inflammatory Bowel Disease Questionnaire score <50, failure to achieve endoscopic remission, and the presence of active extra-intestinal manifestations in both diseases. Disease monitoring with imaging and/or endoscopy during the previous year was conducted in ∼50 % of patients, with endoscopy performed in ∼40 %. Potential therapeutic adjustments were reported for half of the patients. Conclusions: This study highlights SDC in a significant portion of IBD Italian patients. These results emphasize the need for more proactive management strategies in both CD and UC patients.