Relugolix Combination Therapy in Symptomatic Adenomyosis and Uterine Fibroids: A Case Series

Stefania Saponara

Primo

;Maurizio Nicola D'Alterio;Stefano Di Michele;Caterina Chilà;Antonio Maiorana;Michele Vignali;Ludovico Muzii;Stefano Angioni

Ultimo

2026-01-01

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Abstract

Objective: To evaluate the clinical efficacy and safety of a once-daily oral fixed-dosecombination of relugolix 40 mg, estradiol 1 mg, and norethisterone acetate 0.5 mg inwomen with symptomatic adenomyosis coexisting with uterine fibroids.Methods: This case series included six women with uterine fibroids and concomitantadenomyosis, diagnosed by transvaginal ultrasound according to MUSA criteria. Allpatients received continuous treatment for 12 months. Clinical outcomes includedchanges in dysmenorrhea and pelvic pain assessed by the Visual Analogue Scale(VAS), menstrual blood loss evaluated through the Pictorial Blood Assessment Chart(PBAC), and hemoglobin levels. Ultrasonographic assessment measured uterine volumeand adenomyosis-related features before and after treatment.Results: All patients achieved complete resolution of dysmenorrhea and chronic pelvicpain, with VAS scores reduced to zero. Menstrual bleeding ceased in all cases(PBAC = 0), and hemoglobin levels improved after 12 months. Ultrasound examinationdemonstrated a reduction in uterine volume ranging from 8.6% to 58.3%, along withpartial regression of direct adenomyotic features. No adverse events or treatmentdiscontinuations were reported during follow-up.Conclusions: Relugolix/estradiol/norethisterone acetate combination therapy was effec-tive, well-tolerated, and associated with consistent clinical and sonographic improvementin women with adenomyosis and coexisting fibroids. Future larger-scale, controlled studies with extended follow-up are warranted to validate these findings.